JAHA:类风湿关节炎与心力衰竭!

2018-01-20 xing.T MedSci原创

由此可见,在这项队列研究中,RA与HF住院增加有关。这些发现大大增加了RA作为HF的临床相关危险因素的现有证据。

类风湿关节炎(RA)是一种慢性炎症性疾病,与多种疾病并存,包括心血管疾病,但它与心力衰竭(HF)之间的相关性尚不完全明确。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在调查在全国范围内类风湿关节炎患者发生心衰的风险。

该研究纳入了整个丹麦人口中年龄≥18岁的个体,从2008年1月1日开始随访至第一次因心衰而住院、移民、2012年12月31日或死亡。关于合并症、药物和社会经济状况的信息是通过行政登记单级链接来确定。在1978年至2008年期间被诊断为RA的患者被纳入研究。主要研究结局为首次HF入院。研究人员计算了每1000人每年的HF发病率,并根据年龄、性别、历年、合并症、药物、社会经济状况、吸烟和饮酒量等因素进行调整后对发病率进行了估计。

在研究开始时,总共有4305225名无HF病史受试者有资格进行分析。在这些受试者中,有24343名RA患者和50623名患者因HF入院治疗的个体。对照人群(n=49879)和RA患者(n=744)患HF的总发病率分别为2.43和6.64。与此相对应的是,完全调整后RA患者因HF入院治疗有所增加,其发生率为1.30(95%可信区间为1.17-1.45)。

由此可见,在这项队列研究中,RA与HF住院增加有关。这些发现大大增加了RA作为HF的临床相关危险因素的现有证据。

原始出处:

Usman Khalid,et al. Incident Heart Failure in Patients With Rheumatoid Arthritis: A Nationwide Cohort Study.JAHA.2018. https://doi.org/10.1161/JAHA.117.007227

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    2018-04-24 12279fcam93暂无昵称

    学习谢谢分享

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=308921, encodeId=e2fd30892162, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/24/d4dbe9a2f0de1e93fe32ece7cdd3504a.jpg, createdBy=284f2334779, createdName=12279fcam93暂无昵称, createdTime=Tue Apr 24 20:58:53 CST 2018, time=2018-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290591, encodeId=c30129059139, content=与人种因素有关系么, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/25/f9c103b74b05f7c5951ad79adf5be80f.jpg, createdBy=49642274853, createdName=spake, createdTime=Sat Feb 24 19:36:16 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289172, encodeId=223e2891e283, content=不错不错.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/25/595e5d54caa951a782635f11e2e276ef.jpg, createdBy=36b22272394, createdName=121aa00em44暂无昵称, createdTime=Mon Feb 19 11:46:04 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265626, encodeId=36d4126562617, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon Jan 22 01:01:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267696, encodeId=5c72126e69626, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Mon Jan 22 01:01:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333976, encodeId=213a13339e6bb, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Mon Jan 22 01:01:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597351, encodeId=8901159e351e0, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Mon Jan 22 01:01:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280622, encodeId=e9ed280622f3, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jan 21 10:09:59 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-02-24 spake

    与人种因素有关系么

    0

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    2018-02-19 121aa00em44暂无昵称

    不错不错.学习了

    0

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    2018-01-22 lmm397
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    2018-01-22 zhaohui6731
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    2018-01-21 1dd8c52fm63(暂无匿称)

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