JACC：基于生物标志物的冠心病预后预测模型

2017-08-09 MedSci MedSci原创

目前，尚无公认的预测稳定型冠心病预后的模型。近日，在国际心血管权威杂志JACC上发表了一篇旨在比较评估生物标志物和临床指标预测稳定冠心病患者预后的效果的回顾性临床研究。本研究随机纳入了13164名稳定冠心病患者，评估分析了几种不同的生物标志物和临床指标的预测效果，并基于几个主要的标志物应用多变量Cox回归分析建立一个能预测临床预后的模型。主要终点事件是心源性死亡。经过平均3.7年时间的随访

目前，尚无公认的预测稳定型冠心病预后的模型。近日，在国际心血管权威杂志JACC上发表了一篇旨在比较评估生物标志物和临床指标预测稳定冠心病患者预后的效果的回顾性临床研究。

本研究随机纳入了13164名稳定冠心病患者，评估分析了几种不同的生物标志物和临床指标的预测效果，并基于几个主要的标志物应用多变量Cox回归分析建立一个能预测临床预后的模型。主要终点事件是心源性死亡。经过平均3.7年时间的随访，共有591例心源性死亡事件。研究结果显示最重要的三个标志物分别是N末端B型钠尿肽（NT-proBNP）、超敏肌钙蛋白T（hs-cTnT），和低密度脂蛋白胆固醇，其中NT-proBNP和hs-cTnT较其他标志物和临床指标都更有预测价值。最终，预测稳定冠心病患者预后的模型包括年龄[A]、生物标志物（NT-proBNP、hs-cTnT和低密度脂蛋白胆固醇）[B]和一些临床变量（吸烟、糖尿病和外周动脉疾病）[C]，这种ABC模型对心源性死亡有较好的预测能力（c指数0.81）。

研究结果显示，这种ABC预测模型对稳定冠心病患者的心源性死亡事件有很好的预测价值。

原始出处：

Daniel L et al.Biomarker-Based Risk Model to Predict Cardiovascular Mortality in Patients With Stable Coronary Disease.JACC.2017 Aug.

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2018-06-27 hbwxf

#JACC#

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2018-04-29 hukaixun

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2017-08-11 维他命

#预测模型#

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2017-08-11 12498568m50暂无昵称

#ACC#

28 0
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2017-08-11 zhu_jun9842

#生物标志#

31 0
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2017-08-11 zhu_jun9842

#生物标志#

32 0
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2017-08-10 清风拂面

谢谢分享，学习了

54 0

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