J Vet Intern Med:急性肾损伤的主要止血功能

2020-02-27 不详 网络

本研究旨在表征急性肾损伤(AKI)犬的主要止血功能。纳入国际肾病学会AKI III级以上的十只狗和十只健康对照。前瞻性研究比较了两组狗(AKI组与对照组)的PCV,血小板计数,血小板凝集测定法(Multiplate)和von Willebrand因子抗原与胶原蛋白结合活性比率(vWF:Ag:vWF:CBA)。仅在AKI组中测量颊黏膜出血时间。除非另有说明,否则数据以中位数[第25、75%]表示。结

本研究旨在表征急性肾损伤(AKI)犬的主要止血功能。

纳入国际肾病学会AKI III级以上的十只狗和十只健康对照。前瞻性研究比较了两组狗(AKI组与对照组)的PCV,血小板计数,血小板凝集测定法(Multiplate)和von Willebrand因子抗原与胶原蛋白结合活性比率(vWF:Ag:vWF:CBA)。仅在AKI组中测量颊黏膜出血时间。除非另有说明,否则数据以中位数[第25、75%]表示。

结果显示,AKI组的平均PCV显著降低(34.7%;±SD,8.8),低于对照组(46.1%;±SD,3.6; P <0.001)。AKI(350.5××103 /μL[301,516])的血小板计数明显高于对照组(241××103 /μL[227,251]; P = .01)。AKI(36.9±17.7)曲线下面积测量的胶原激活血小板凝集法显著低于对照组(54.9±11.2; P = .05)。AKI中的vWF:Ag:vWF:CBA(2.2 [1.9,2.6])明显高于对照组(1.1 [1.1,1.2]; P = .01)。vWF:Ag:vWF:CBA与肌酐之间有很强的相关性(r = 0.859; P <0.001),但没有其他变量。

该结果表明,高vWF:Ag:vWF:CBA表明,患有AKI的狗的胶原蛋白活化的血小板聚集减少,并且似乎具有II型von Willebrand病样表型。

原始出处:

Duana McBride, Rosanne E. Jepson, et al., Primary hemostatic function in dogs with acute kidney injury. J Vet Intern Med. 2019 Sep-Oct; 33(5): 2029–2036.  doi: 10.1111/jvim.15588

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