DIABETOLOGIA:2型糖尿病患者因心力衰竭住院的风险过高

2018-12-23 MedSci MedSci原创

2型糖尿病是心力衰竭的既定的风险因素,但目前仍缺乏相关的年龄特异性数据。本研究的目的是与来自一般人群的年龄和性别匹配的对照个体进行比较,确定基于年龄,血糖控制和肾功能的心力衰竭的过度风险。 研究人员将1998 - 2012年瑞典国家糖尿病登记处(n  = 266,305)登记的2型糖尿病患者与未患糖尿病的年龄,性别和县匹配对照组进行比较(n  = 1,323,504),随

2糖尿病是心力衰竭的既定的风险因素,但目前仍缺乏相关的年龄特异性数据。本研究的目的是与来自一般人群的年龄和性别匹配的对照个体进行比较,确定基于年龄,血糖控制和肾功能的心力衰竭的过度风险。

研究人员将1998 - 2012年瑞典国家糖尿病登记处(n  = 266,305)登记的2糖尿病患者与未患糖尿病的年龄,性别和县匹配对照组进行比较(n  = 1,323,504),随访中位数为5.6岁截至到20131231日。

结果显示。本研究共确定了266,3052型糖尿病患者(平均年龄62.0岁,45.3%女性)和1,323,504名对照者。在患有2型糖尿病和对照个体的个体中,18,7157.0%)和50,1573.8%)分别诊断为心力衰竭。将糖尿病患者与对照组患者进行比较,年龄小于55岁的2型糖尿病男性和女性患心衰的住院率为分别为2.0795CI 1.73,2.48)和4.5995CI 3.50,6.02),分别使用针对社会经济变量和相关条件进行调整的分析后,与对照组相比,年龄较小,血糖控制较差和肾功能恶化均与2型糖尿病患者心力衰竭的过度风险增加有关。然而,糖尿病患者75岁,无蛋白尿或血糖控制良好(HbA1c ≤52毫摩尔/摩尔[≤6.9]))与有住院心脏衰竭同一年龄组对照个体类似的风险。

研究表明,患有2型糖尿病的年龄<55岁的男性和女性患心力衰竭的风险显著增加。超额风险随着年龄的增长而下降,但即使血糖控制良好也会持续存在。然而,在75岁及以上的人群中,血糖水平控制良好或无白蛋白尿的糖尿病患者心脏衰竭的风险与非糖尿病患者相当。

原始出处:

Annika Rosengren, Jon Edqvist, Araz Rawshani, Excess risk of hospitalisation for heart failure among people with type 2 diabetes

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    2018-12-23 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2018-12-23 医者仁心5538

    学习了

    0

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心力衰竭是1型糖尿病患者死亡的主要原因之一。因此,心力衰竭早期诊断对1型糖尿病至关重要。 为此,来自丹麦Steno糖尿病中心的Jensen教授及其团队进行了一项研究,试图确定在没有已知心脏病的1型糖尿病患者中,亚临床心脏收缩和舒张功能受损相关的患病率和临床特征。该研究结果发表在2014年04月的Diabetologia杂志上。 该研究是一项横断面调查,从Steno糖尿病中心随机选择了1093例