Redox Biol:研究揭示活性羰基醛发起的反馈机制,为老化和退化性疾病提供重要参考

2017-09-21 Emma MedSci原创

能量的生产不可避免地与有毒代谢物如活性氧和羰基物质等的生成有关,它们被认为是老化和退化性疾病的主要原因。对于细胞如何适应能量通量的升高,伴随着有害副产物的积累而不会造成任何损害仍是未知。

能量的生产不可避免地与有毒代谢物如活性氧和羰基物质等的生成有关,它们被认为是老化和退化性疾病的主要原因。对于细胞如何适应能量通量的升高,伴随着有害副产物的积累而不会造成任何损害仍是未知。

发表于Redox Biol的一篇文章中,研究人员研究了酵母细胞中葡萄糖浓度突然升高的影响,希望能为相关研究提供参考。该研究揭示了由活性羰基醛发起一种反馈机制,在糖酵解过程中非酶促形成,也表明代谢和蛋白毒性应激之间的直接联系以及RCS( reactive carbonyl species)通过在增加代谢压力时启动激素反应的保护作用。通过特定的治疗干预措施(例如分子伴侣系统)来针对这种反应的不同水平和调节因子,可能开辟药物开发和治疗涉及RCS和ROS水平升高的疾病的新领域,如糖尿病和神经退行性疾病。

低剂量的MG诱导酵母细胞对于MG和ROS(reactive oxygen species)毒性水平的耐受,这种预处理效果是通过多层次的防御机制进行的,由预防,解毒和损伤缓解组成。低MG诱导PQS,包括通过HSP的蛋白质分选和处理。后者由蛋白质质量控制系统介导,需要可诱导的Hsp70和Btn2,即螯合蛋白质折叠的聚集酶。这种糖运动机制使细胞能够预先适应上升的能量通量并直接将代谢与蛋白毒性应激相关联。此外,进一步的分析表明在内皮细胞中存在相似的反应。

原始出处:
Zemva J, et al. Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux. Redox Biol. 2017 Oct;13:674-686. doi: 10.1016/j.redox.2017.08.007.

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    2017-09-30 一个字-牛

    学习了谢谢分享

    0

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    2018-06-29 柳叶一刀
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    2017-09-24 ren1mw

    学习一下!谢谢分享

    0

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    2017-09-23 ren1mw

    学习一下!谢谢分享

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1767227, encodeId=2f671e672273a, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sun Oct 15 05:14:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248973, encodeId=e4c72489e377, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat Sep 30 06:07:20 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917659, encodeId=b19d191e659da, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Jun 29 14:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247187, encodeId=eac324e18785, content=学习一下!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sun Sep 24 07:42:17 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247042, encodeId=e58e24e0423d, content=学习一下!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sat Sep 23 20:58:19 CST 2017, time=2017-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388008, encodeId=d5331388008d5, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Sep 23 04:14:00 CST 2017, time=2017-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246386, encodeId=1982246386e0, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 21 19:58:56 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246332, encodeId=0b84246332d2, content=学习一下!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Thu Sep 21 13:27:32 CST 2017, time=2017-09-21, status=1, ipAttribution=)]
    2017-09-21 李东泽

    是很好的学习材料.不错.以后会多学习.

    0

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    2017-09-21 ren1mw

    学习一下!谢谢分享!

    0

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近期有研究表明,与高动物蛋白摄入量相比,高植物蛋白摄入量与死亡率成负相关,而高动物蛋白摄入量与死亡率成正相关。研究人员报告说,用植物蛋白替代动物蛋白可能会导致相当大的健康益处,特别是对于那些有其他不健康的行为或条件的人来说。来自马萨诸塞州总医院和哈佛医学院的Mingyang Song博士和同事们进行了一项研究,探究不同蛋白质来源对宏观均衡饮食的影响,以及研究了动物和植物蛋白摄入与死亡风险的关系。该