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J Gastroen Hepatol：英利昔单抗抢救急性重症溃疡性结肠炎的疗效预测

2018-07-12 zhangfan MedSci原创

急性重症溃疡性结肠炎英夫利昔单抗CRP/白蛋白
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研究认为，基线Mayo内镜得分以及CRP/白蛋白比值可对英夫利昔单抗抢救治疗后急性重症溃疡性结肠炎患者预后进行预测，但英夫利昔单抗强化治疗不能降低患者结肠切除率

急性重症溃疡性结肠炎(ASUC)是一种需要及时治疗的紧急医疗事件。虽然英夫利昔单抗作为ASUC抢救疗法已经使用了15年，但目前仍缺乏临床治疗成功的预测指标。近日研究人员就英夫利昔单抗用于ASUC治疗的指导剂量以及结肠切除相关因素进行了考察。

54例ASUC住院患者接受英夫利昔单抗治疗，随访12个月，主要终点为结肠切除，并对英夫利昔单抗强化(AI)和标准(SI)诱导策略效果进行了比较。

54名患者中，2人未完成随访。52人中，8人3个月后接受结肠切除（15.38%），14人12个月后接受结肠切除（26.92%）。AI治疗组患者结肠切除率高于SI组，但AI治疗组患者疾病症状更为严重。英夫利昔单抗治疗后至出院前C反应蛋白(CRP)/白蛋白率0.37是预测结肠切除事件的有效生化指标，其接受者曲线下面积为0.73，但治疗前CRP及白蛋白水平不能预测患者预后。基线Mayo内镜评分2人群在英夫利昔单抗治疗可免于结肠切除，其阳性预测率为94%。

研究认为，基线Mayo内镜得分以及CRP/白蛋白比值可对英夫利昔单抗抢救治疗后急性重症溃疡性结肠炎患者预后进行预测，但英夫利昔单抗强化治疗不能降低患者结肠切除率。

原始出处：


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    2019-02-07 nymo

    #溃疡性#

    0

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    2018-11-19 ms24272190615788285182

    #AST#

    0

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    2018-12-06 许安

    #GAS#

    0

  4. 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encryptionId=ac13558e9cb, topicName=抢救)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be1a7117101, createdName=lfyang, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559898, encodeId=d6131559898d7, content=<a href='/topic/show?id=81658e0779d' target=_blank style='color:#2F92EE;'>#英利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87077, encryptionId=81658e0779d, topicName=英利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=589415038604, createdName=bnjfx@131.com, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565907, encodeId=4226156590ed0, content=<a href='/topic/show?id=81658e0779d' target=_blank style='color:#2F92EE;'>#英利昔单抗#</a>, beContent=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:01:00 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-19 张新亮1853311252142e2fm

    好文献学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1695035, encodeId=76271695035d7, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Feb 07 05:11:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711561, encodeId=b22b1e1156178, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:01:00 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-13 gwc384

    #EPA#

    0

  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:01:00 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-13 lfyang

    #抢救#

    0

  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:01:00 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-13 bnjfx@131.com

    #英利昔单抗#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1695035, encodeId=76271695035d7, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Feb 07 05:11:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711561, encodeId=b22b1e1156178, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encryptionId=ac13558e9cb, topicName=抢救)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be1a7117101, createdName=lfyang, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559898, encodeId=d6131559898d7, content=<a href='/topic/show?id=81658e0779d' target=_blank style='color:#2F92EE;'>#英利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87077, encryptionId=81658e0779d, topicName=英利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=589415038604, createdName=bnjfx@131.com, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565907, encodeId=4226156590ed0, content=<a href='/topic/show?id=81658e0779d' target=_blank style='color:#2F92EE;'>#英利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87077, encryptionId=81658e0779d, topicName=英利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=589415038604, createdName=bnjfx@131.com, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331342, encodeId=72bb33134227, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jul 13 18:26:04 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331254, encodeId=3ab533125465, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:01:00 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-13 bnjfx@131.com

    #英利昔单抗#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1695035, encodeId=76271695035d7, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Feb 07 05:11:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711561, encodeId=b22b1e1156178, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon Nov 19 07:11:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072227, encodeId=baf420e222799, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Thu Dec 06 19:11:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332656, encodeId=04d63326565e, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, 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encryptionId=ac13558e9cb, topicName=抢救)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be1a7117101, createdName=lfyang, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559898, encodeId=d6131559898d7, content=<a href='/topic/show?id=81658e0779d' target=_blank style='color:#2F92EE;'>#英利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87077, encryptionId=81658e0779d, topicName=英利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=589415038604, createdName=bnjfx@131.com, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565907, encodeId=4226156590ed0, content=<a href='/topic/show?id=81658e0779d' target=_blank style='color:#2F92EE;'>#英利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87077, encryptionId=81658e0779d, topicName=英利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=589415038604, createdName=bnjfx@131.com, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331342, encodeId=72bb33134227, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jul 13 18:26:04 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331254, encodeId=3ab533125465, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:01:00 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-13 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

  10. 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createdName=张新亮1853311252142e2fm, createdTime=Thu Jul 19 07:51:18 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427161, encodeId=3ebc142e161bf, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471338, encodeId=0bbc14e133843, content=<a href='/topic/show?id=ac13558e9cb' target=_blank style='color:#2F92EE;'>#抢救#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55879, encryptionId=ac13558e9cb, topicName=抢救)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be1a7117101, createdName=lfyang, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559898, encodeId=d6131559898d7, content=<a href='/topic/show?id=81658e0779d' target=_blank style='color:#2F92EE;'>#英利昔单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87077, encryptionId=81658e0779d, topicName=英利昔单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=589415038604, createdName=bnjfx@131.com, createdTime=Fri Jul 13 22:11:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565907, encodeId=4226156590ed0, content=<a href='/topic/show?id=81658e0779d' target=_blank style='color:#2F92EE;'>#英利昔单抗#</a>, beContent=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:01:00 CST 2018, time=2018-07-13, status=1, ipAttribution=)]
    2018-07-13 kafei

    学习了谢谢

    0

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