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CLIN CANCER RES：CART19治疗难治/复发急性淋巴细胞白血病

2017-07-08 MedSci MedSci原创

cARTCD19急性淋巴细胞白血病
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复发/难治急性淋巴细胞白血病（R/R ALL）患者预后较差。CART19具有抗白血病作用。但是中国患者的系统化试验数据尚缺乏。CLIN CANCER RES近期发表了一篇文章，报道中国CART19治疗急性淋巴细胞白血病的试验结果。

复发/难治急性淋巴细胞白血病（R/R ALL）患者预后较差。CART19具有抗白血病作用。但是中国患者的系统化试验数据尚缺乏。CLIN CANCER RES近期发表了一篇文章，报道中国CART19治疗急性淋巴细胞白血病的试验结果。

研究共纳入15例R/R ALL患者。观察患者的输液后反应、毒性、CART19s扩增及持续性。CART19s平均转换效率为33%。体外毒性实验表明CART19s具有强大的抗白血病能力。患者接受CART19s输入剂量为1.1×106/kg到9.8×106/kg。12例患者在CART19s输入1个月后达到完全缓解。CART19s在外周血及骨髓中持续存在并扩增。在150天，总生存率和无病生存率分别为65.5%和37.8%。累计的复发和非复发死亡率分别为54.5%和7.7%。4例患者接受了后续的干细胞移植治疗。在该试验中10例患者出现细胞因子释放综合征（CRS）。在40%的患者中出现3级CRS，CRS与第1天更高的疾病负担以及更多地复发次数有关。

文章最后认为，该试验表明对于中国R/R ALL患者CART19s具有抗白血病活性。疾病复发仍然是最大的障碍。CART19s治疗后复发风险高的患者可能受益于后续的干细胞移植治疗。

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    2017-10-24 仁者大医

    #CART19#

    0

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    2017-08-09 sunyl07

    #淋巴细胞白血病#

    0

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content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 09 00:02:38 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-10 wetgdt

    #淋巴细胞#

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Jul 09 07:20:58 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220121, encodeId=2f3222012172, content=这个学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jul 09 00:09:46 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220112, encodeId=1c22220112e1, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 09 00:02:38 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-10 zhaojie88

    #ART#

    0

  5. 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content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 09 00:02:38 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-10 ms2999106592497887

    #cART#

    0

  6. 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content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 09 00:02:38 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-10 jyzxjiangqin

    复发急性淋巴细胞白血病。

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Jul 10 07:18:33 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220230, encodeId=c2512202306d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4KDsF1g1gUHzGM0LHxX5B5uhEMln8y8iagso9N4XBTQVPmHrCNoT3o8bw80Ds53TpTgcPnKUIfkyw/0, createdBy=bc101976400, createdName=suibian2007bbb, createdTime=Sun Jul 09 08:13:50 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220190, encodeId=f32d220190e3, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Jul 09 07:20:58 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220121, encodeId=2f3222012172, content=这个学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jul 09 00:09:46 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220112, encodeId=1c22220112e1, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 09 00:02:38 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-09 suibian2007bbb

    学习

    0

  8. 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content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 09 00:02:38 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-09 ylzr123

    好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！

    0

  9. 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content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 09 00:02:38 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-09 飛歌

    这个学习了很有用

    0

  10. 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content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 09 00:02:38 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-09 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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