Nature Microbiology:欣喜!广谱埃博拉病毒疫苗新突破

2018-05-10 小通 生物通

Nature Microbiology》发文,联合课题组成功研制出新型埃博拉抗体,这种抗体可用于多种埃博拉病毒治疗。


《Nature Microbiology》发文,联合课题组成功研制出新型埃博拉抗体,这种抗体可用于多种埃博拉病毒治疗。

埃博拉病毒(Ebola virus)危及全球健康,感染后死亡率很高。科学家们开发了几种策略,包括在非人类灵长类动物身上已经看到成效的ZMapp,而且已被纳入人类关怀治疗手册(compassionate-treatment protocols)使用范围。

“ZMapp的问题在于,它对最近爆发的埃博拉疫情有较好的效果,但是它对其他埃博拉病毒株,包括Bundibugyo、Reston或Sudan都没有中和效果,”德州大学Galveston医学分部教授、病毒学家Alex Bukreyev说。“我们在感染Bundibugyo ebolavirus的人类幸存者体内鉴定了三种天然抗体,它们对几种不同埃博拉病毒都有中和和保护作用。”新发现的抗体与埃博拉病毒的结合位点与以往发现抗体的不同。

有关埃博拉病毒:

据疾控中心报道,埃博拉病毒的首次发现地点是刚果民主共和国埃博拉河附近(1976年),自那以后,该病毒不时感染人类,在非洲等国多次导致疫情爆发。

埃博拉病毒的常见种类:

埃博拉病毒(Ebola virus) 即扎伊尔埃博拉病毒(Zaire ebolavirus)

苏丹病毒(Sudan virus),即苏丹埃博拉病毒(Sudan ebolavirus)

塔伊森林病毒(Ta? Forest virus ),即塔伊森林埃博拉病毒,原名科特迪瓦埃博拉病毒(Ta? Forest ebolavirus, formerly C?te d'Ivoire ebolavirus)

本迪布焦病毒(Bundibugyo virus),即本迪布焦埃博拉病毒(Bundibugyo ebolavirus)

莱斯顿病毒(Reston virus ),即已知在非人灵长类动物和猪中致病,但不引起人类疾病的莱斯顿埃博拉病毒(Sudan ebolavirus)

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    2019-01-22 liye789132251
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    2019-04-01 xjy02
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    2019-01-06 sunylz
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