JCEM：子宫肌瘤中，黄体酮调控sFRP4表达

2017-06-30 MedSci MedSci原创

尽管已了解黄体酮对子宫平滑肌肿瘤的发生起着关键性作用，但对其促进子宫肌瘤生长的机制仍然知之甚少。来自休斯敦的研究人员探讨了并确定了介导孕激素作用于子宫肌瘤的新的基因产物。研究人员假定在子宫平滑肌瘤中有不同表达的调控黄体酮的基因，并使用基因表达分析确定，然后进行了体外研究。采用Illumina WG Bead Chip (v2.6) 全面分析基因表达，同时使用一种将已知蛋白质的相互作用整合起来的生物

尽管已了解黄体酮对子宫平滑肌肿瘤的发生起着关键性作用，但对其促进子宫肌瘤生长的机制仍然知之甚少。来自休斯敦的研究人员探讨了并确定了介导孕激素作用于子宫肌瘤的新的基因产物。

研究人员假定在子宫平滑肌瘤中有不同表达的调控黄体酮的基因，并使用基因表达分析确定，然后进行了体外研究。采用Illumina WG Bead Chip (v2.6) 全面分析基因表达，同时使用一种将已知蛋白质的相互作用整合起来的生物信息学算法分析。孕激素受体（PR）的基因结合位点通过染色质免疫共沉淀（Chromatin Immunoprecipitation, ChIP）来确定。应用siRNA研究原代细胞系的基因功能。

经过分析，研究人员发现，分泌型卷曲相关蛋白4(SFRP4)是一个PR激活相关的重要基因产物，它在子宫肌瘤中的表达比肌层中高2.6倍（n＝26，P＜0.01），而且，在月经周期的增殖期升高2.5倍（n = 26，P＜0.01）。在ChIP-qPCR中观察到PR和sFRP4启动子之间的直接结合。来自子宫肌瘤的原代细胞培养中也观察到sFRP4的过量表达。在平滑肌瘤细胞中，黄体酮通过雌二醇优先抑制sFRP4表达和分泌，且致敏方式具有剂量依赖性。在子宫肌瘤和平滑肌瘤中，敲除sFRP4基因都能抑制原代细胞系的增殖和凋亡。

子宫肌瘤中的sFRP4的过量表达中由黄体酮调节，且能增强平滑肌增殖。未来需要进一步黄体酮是如何调节sFRP4的表达。进而促进子宫平滑肌瘤进展的。

原始出处：

Delaney MA, Wan YW,et al.A Role for Progesterone-Regulated sFRP4 Expression in Uterine Leiomyomas.J Clin Endocrinol Metab. 2017 Jun 14. doi: 10.1210/jc.2016-4014. [Epub ahead of print]

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2017-09-27 爆笑小医

#JCEM#

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2018-05-23 oliver179

#黄体酮#

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2017-08-24 achengzhao

#JCE#

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2017-07-18 jyzxjiangqin

子宫肌瘤。

49 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Jul 05 00:36:15 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
2017-07-12 189****7206

学习了谢谢分享

67 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Jul 05 00:36:15 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
2017-07-10 184****9840

学习了受益匪浅

61 0
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2017-07-09 139****5926

好好文章学习了

66 0
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objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Jul 09 07:30:41 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219761, encodeId=97aa219e6166, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Jul 08 07:01:17 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218649, encodeId=b92d2186494a, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Jul 05 00:36:15 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
2017-07-09 jyzxjiangqin

子宫肌瘤的相关问题。

61 0
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Mon Jul 10 06:22:02 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220415, encodeId=b652220415c4, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sun Jul 09 22:13:45 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220199, encodeId=d181220199f9, content=子宫肌瘤的相关问题。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Jul 09 07:30:41 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219761, encodeId=97aa219e6166, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Jul 08 07:01:17 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218649, encodeId=b92d2186494a, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Jul 05 00:36:15 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
2017-07-08 130****4638

学习了受益匪浅

32 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Jul 05 00:36:15 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
2017-07-05 130****4638

学习了谢谢分享

27 0

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