Blood:CXCL1通过调节中性粒细胞稳态参与宿主免疫防御

2019-02-06 MedSci MedSci原创

中性粒细胞迁移至细胞感染的位置是机体免疫防御的重要一步。中性粒细胞从骨髓中产生到释放入血均受到严格的调控。尽管现已明确趋化因子CXCL1在细菌感染的过程中可诱导中性粒细胞的迁移,但其在肺炎诱导性脓毒症中调节中性粒细胞募集、粒细胞生成和中性粒细胞动员的作用尚未十分明确。现Sagar Paudel等人通过肺内肺炎链球菌感染的小鼠模型来研究CXCL1在宿主防御、粒细胞生成和中性粒细胞动员中的作用。研究结

中性粒细胞迁移至细胞感染的位置是机体免疫防御的重要一步。中性粒细胞从骨髓中产生到释放入血均受到严格的调控。尽管现已明确趋化因子CXCL1在细菌感染的过程中可诱导中性粒细胞的迁移,但其在肺炎诱导性脓毒症中调节中性粒细胞募集、粒细胞生成和中性粒细胞动员的作用尚未十分明确。

现Sagar Paudel等人通过肺内肺炎链球菌感染的小鼠模型来研究CXCL1在宿主防御、粒细胞生成和中性粒细胞动员中的作用。研究结果显示CXCL1可增加中性粒细胞的流入,控制肺部细胞的生长和细菌的扩散,从而提高宿主的存活率。

Cxcl1-/-小鼠具有粒细胞间室内早期中性粒细胞前体的扩增缺陷、CD62L和CD49d依赖性的中性粒细胞释放受损,进一步证实了CXCL1的功能。感染后予以重组CXCL2和CXCL5可修复Cxcl1-/-小鼠的中性粒细胞依赖性的宿主免疫防御。

总而言之,本研究表明CXCL1在革兰氏阳性肺炎所致脓毒症中的宿主防御、粒细胞生成和中性粒细胞动员中发挥中心作用。

原始出处:

Sagar Paudel, et al.CXCL1 regulates neutrophil homeostasis in pneumonia-derived sepsis caused by Streptococcus pneumoniae serotype 3.Blood 2019 :blood-2018-10-878082; doi: https://doi.org/10.1182/blood-2018-10-878082 

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    2019-02-11 wetgdt
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    2019-02-10 changfy
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    2019-02-08 wincls
  6. [GetPortalCommentsPageByObjectIdResponse(id=1757386, encodeId=fe551e573866d, content=<a href='/topic/show?id=a37046502b2' target=_blank style='color:#2F92EE;'>#宿主免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46502, encryptionId=a37046502b2, topicName=宿主免疫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cef37318374, createdName=ms3875500703114551, createdTime=Wed Feb 20 17:25:00 CST 2019, time=2019-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783992, encodeId=c80d1e83992a0, content=<a href='/topic/show?id=aa8d553574' target=_blank style='color:#2F92EE;'>#CXCL1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5535, encryptionId=aa8d553574, topicName=CXCL1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Mon Feb 11 20:25:00 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646731, encodeId=c84d1646e319e, content=<a href='/topic/show?id=4478e5315e1' target=_blank style='color:#2F92EE;'>#稳态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75315, encryptionId=4478e5315e1, topicName=稳态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ebc23344390, createdName=changfy, createdTime=Sun Feb 10 05:25:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296693, encodeId=a130129669316, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Fri Feb 08 04:25:00 CST 2019, time=2019-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404723, encodeId=fc0e1404e230b, content=<a href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46499, encryptionId=1a4f4649925, topicName=宿主)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/08904ED76550A0090DB220A7FB81D755/100, createdBy=78512492586, createdName=wincls, createdTime=Fri Feb 08 04:25:00 CST 2019, time=2019-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360057, encodeId=e35936005e8f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Wed Feb 06 15:53:28 CST 2019, time=2019-02-06, status=1, ipAttribution=)]
    2019-02-06 衣带渐宽

    学习

    0