Stroke: 大血管闭塞患者行机械性血栓切除术术后的临床结果与HbA1c(糖化血红蛋白)水平分析

2019-01-13 MedSci MedSci原创

之前有文献报道了机械血栓切除术(MT)治疗大血管闭塞患者的HbA1c(糖化血红蛋白)水平与临床结果之间的关系,因此本项研究旨在就这一问题进行进一步探究。

背景和目的
之前有文献报道了机械血栓切除术(MT)治疗大血管闭塞患者的HbA1c(糖化血红蛋白)水平与临床结果之间的关系,因此本项研究旨在就这一问题进行进一步探究。

方法
本项前瞻性队列研究共纳入534例MT治疗的急性缺血性卒中(AIS)患者。根据HbA1c水平,测量的主要结果是3个月时改良的Rankin量表评分。高HbA1c水平定义为血浆HbA1c水平> 6.5%。有利结果被定义为功能独立,改良Rankin量表评分为0至2.次要功能结果包括死亡率,早期临床结果和颅内出血。

结果
HbA1c> 6.5%的患者预后良好的患者数明显低于HbA1c≤6.5%的患者(28.8%VS42.1%; P = 0.006)。在多变量分析中,高剂量的HbA1c水平(特别是> 7.0%HbA1c)与用MT治疗大血管闭塞患者AIS后3个月的功能不良结果显着相关。在用MT治疗的患者中,高HbA1c也与AIS后死亡率增加和早期临床结果显着相关。亚组分析显示,与再通组和非再通组患者相比,AIS后3个月HbA1c> 6.5%与功能独立的几率显着降低相关。

结论
本项研究结果表明,在用MT治疗的大血管闭塞患者中,高HbA1c水平是AIS后3个月不良预后的独立预测因子,特别是在血管再通的患者中可能增加AIS后死亡和早期临床恶化的风险。

原始出处:

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    2019-04-18 kkunny
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    2019-12-25 智智灵药
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1706136, encodeId=bffa1e06136da, content=<a href='/topic/show?id=7f6443986ec' target=_blank style='color:#2F92EE;'>#大血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43986, encryptionId=7f6443986ec, topicName=大血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caff31165455, createdName=kkunny, createdTime=Thu Apr 18 03:59:00 CST 2019, time=2019-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2015945, encodeId=3faf2015945c2, content=<a href='/topic/show?id=33108494c1' target=_blank style='color:#2F92EE;'>#HbA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8494, encryptionId=33108494c1, topicName=HbA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed Dec 25 22:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877111, encodeId=f31618e7111c0, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Oct 14 01:59:00 CST 2019, time=2019-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898817, encodeId=82b6189881e42, content=<a href='/topic/show?id=729322969b9' target=_blank style='color:#2F92EE;'>#临床结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22969, encryptionId=729322969b9, topicName=临床结果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Fri Feb 08 04:59:00 CST 2019, time=2019-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009850, encodeId=b8c4200985092, content=<a href='/topic/show?id=467789803a9' target=_blank style='color:#2F92EE;'>#血管闭塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89803, encryptionId=467789803a9, topicName=血管闭塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Mon May 13 15:59:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358173, encodeId=46a53581e31b, content=认真学习,不断进步,把经验分享给同好。点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Tue Jan 15 08:19:16 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314270, encodeId=cce113142e038, content=<a href='/topic/show?id=585189089f4' target=_blank style='color:#2F92EE;'>#血栓切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89089, encryptionId=585189089f4, topicName=血栓切除)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Tue Jan 15 04:59:00 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401024, encodeId=639214010249e, content=<a href='/topic/show?id=4a328909094' target=_blank style='color:#2F92EE;'>#血栓切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89090, encryptionId=4a328909094, topicName=血栓切除术)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaZNoEMO3BP2wXbOyFTHLDM0NM4jtMZVRFjy61kQCBKjzhYeGClbvzoxiccabPRrcEaq76VWKCSNCQUqAxDnOd4w/132, createdBy=0a332291710, createdName=shuangle, createdTime=Tue Jan 15 04:59:00 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404901, encodeId=14181404901b3, content=<a href='/topic/show?id=40d4612555f' target=_blank style='color:#2F92EE;'>#机械性血栓切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61255, encryptionId=40d4612555f, topicName=机械性血栓切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16bc2501320, createdName=zlawrance, createdTime=Tue Jan 15 04:59:00 CST 2019, time=2019-01-15, status=1, ipAttribution=)]
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    2019-01-15 lietome15

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

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