JAMA:HIV感染者侵袭性未分型流感病毒感染发病率增加

2019-12-23 MedSci MedSci原创

近年来,HIV感染者中侵袭性未分型流感病毒感染的发病率显著增加

侵袭性未分型流感嗜血杆菌(N TH I)感染通过与成人细菌性肺炎有关。近日研究人员就男性HIV人群侵入性NTHi感染情况进行了考察。

研究收录截至2018年底18岁或18岁以上的成年侵入性NTHi感染病例,分析NTHi分离株的时间周期、HIV状态和遗传相关性。研究的主要终点为HIV感染者侵袭性NTHi感染的发生率(2008-2016年和2017-2018年),与2008-2018年非HIV感染者的NTHi感染率相比。在18-55岁有侵袭性NTHi感染的人群中评估次要结果,包括流行病学、临床和地理聚类比较。

553例成人侵袭性NTHi感染患者,平均年龄,66岁,52%为男性,38%为黑人,其中60例为HIV感染者。2017-2018年HIV感染者侵袭性NTHi感染率(每100000人中有41.7例病例)明显高于2008-2016年(9.6/100000)和2008-2018年非HIV感染者(1.1/100000)。2017-2018年期间,在18至55岁感染侵入性 nthi 感染的成年人中(n=179),与2008-2018年期间未感染艾滋病毒的人(n=124)相比,艾滋病毒感染者(n=31)中男性(分别为94%vs49%;)、黑人(100%vs53%)和脓毒性关节炎(35%vs1%)的比例较高。2017-2018年感染侵袭性NTHi的HIV患者(n=31)比2008-2016年感染侵袭性NTHi的HIV患者(n=24)脓毒性关节炎(35%和4%)的比例较高。凝胶电泳对179株18-55岁NTHi分离物中的174株进行了鉴定,确定了2个不同的基因克隆群:簇1(C1;n=24)和簇2(C2;n=23)。全基因组测序证实了NTHI感染的2个克隆谱系,并显示所有C1分离株(但没有一个C2分离株)携带IS1016(一个与H流感包膜基因相关的插入序列)。2017-2018年HIV感染者中C1或C2侵袭性NTHI感染率(28/31[90%])明显高于2008-2016年HIV感染者(10/24[42%])和2008-2018年未感染HIV者(9/119[8%])。与2008-2016年相比,2017-2018年艾滋病毒感染者(10/24[42%])感染 c1或 c2侵入性 NTHi的可能性显著增加(28/31[90%]),而2008-2018年未感染艾滋病毒者(9/119[8%])感染 c1或 c2侵入性 NTHi的可能性显著增加。

近年来,HIV感染者中侵袭性未分型流感病毒感染的发病率显著增加。

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    2019-12-25 sunyl07
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    2019-12-23 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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