J Gastroen Hepatol:腹泻型肠易激综合征患者胰腺功能研究

2017-10-15 zhangfan MedSci原创

研究认为,大部分腹泻型肠易激综合征患者的胰腺功能正常,严重胰腺外分泌不足患者的比例远低于先前的报道

之前的研究统计称约6.1%的腹泻型肠易激综合征患者(IBS-D)存在严重的胰腺外分泌不足(PEI)。近日研究人员利用粪弹性蛋白酶测试考察门诊出现不明原因的慢性腹痛、腹泻以及IBS-D 患者的PEI患病率。

40岁以上,连续至少3个月出现慢性腹痛、腹泻以及IBS-D患者参与本次研究。研究人员采集患者的粪便样本,采用酶联免疫吸附试验测定弹性蛋白酶浓度。弹性蛋白酶浓度低于100 mcg/g可认定为严重PEI,100-200 mcg/g为中度PEI。对于中重度PEI患者进行内镜超声或腹部CT诊断胰腺病理。

研究招募了280名患者,平均年龄60岁,29.4%为男性。研究发现了10名PEI患者,发病率为4.6%,其中重度PEI患者5人,发病率为2.3%。多因素分析显示,男性以及严重嗜酒与胰腺功能异常显著相关。进一步的胰腺病理分析发下,2名患者存在慢性胰腺炎症状。

研究认为,大部分腹泻型肠易激综合征患者的胰腺功能正常,严重胰腺外分泌不足患者的比例远低于先前的报道。

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    2017-11-17 许安
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    2017-10-22 thlabcde

    好资料学习了!

    0

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    2017-10-17 yunger

    很好看.学习了

    0

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    2017-10-16 gwc384
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    2017-10-15 戒馋,懒,贪

    谢谢分享.学习了

    0

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    2017-10-15 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2017-10-15 186****0580(小山羊)

    学学习了

    0

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