慢性淋巴细胞白血病:Calquence达到III期临床试验的主要终点

2019-05-07 不详 网络

阿斯利康本周二宣布,在先前治疗的慢性淋巴细胞白血病(CLL)患者中,Calquence(acalabrutinib)的III期试验(ASCEND研究)将在达到其主要终点后提前停止。

阿斯利康本周二宣布,在先前治疗的慢性淋巴细胞白血病CLL)患者中,Calquenceacalabrutinib)的III期试验(ASCEND研究)将在达到其主要终点后提前停止。

ASCEND研究中,310名先前接受过治疗的CLL患者被随机分配接受Calquence单药治疗或利妥昔单抗联合idelalisib或苯达莫司汀。该试验的主要终点是由独立审查委员会评估的无进展生存期(PFS),而关键的次要终点包括总体反应率、反应持续时间以及总体生存率。结果显示,与利妥昔单抗联合idelalisib或苯达莫司汀的组合方案相比,Calquence单一疗法与PFS的改善显著相关。


原始出处:

http://www.firstwordpharma.com/node/1639080#axzz5nC823Px1

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time=2019-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594589, encodeId=c9b11594589b0, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Thu May 09 12:25:00 CST 2019, time=2019-05-09, status=1, ipAttribution=)]
  5. 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time=2019-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594589, encodeId=c9b11594589b0, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Thu May 09 12:25:00 CST 2019, time=2019-05-09, status=1, ipAttribution=)]
    2020-03-02 juliusluan78
  6. 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