NEJM:利拉鲁肽治疗青少年肥胖

2020-05-28 MedSci原创 MedSci原创

在肥胖症青少年中,使用利拉鲁肽联合生活方式干预可显著降低患儿BMI

目前儿童肥胖的治疗药物十分有限,近日研究人员考察了利拉鲁肽对肥胖青少年的治疗效果。
 
12-18岁,仅靠改变生活方式效果不显著的肥胖青少年参与研究,在生活方式干预基础上,随机接受利拉鲁肽(3.0毫克)或安慰剂,每天皮下注射一次。研究的主要终点是第56周体重指数(BMI)标准差得分与基线的变化。
 
125名参与者接受利拉鲁肽,126名接受安慰剂。在第56周时,利拉鲁肽组的BMI标准差得分与基线相比优于安慰剂(估计差异:-0.22)。利拉鲁肽组113名受试者中有51人,安慰剂组105名受试者中有20人的BMI分别下降了至少5%(43.3% vs 18.7%),两组分别有33名和9名参与者的BMI分别下降了至少10%(26.1%vs8.1%)。与安慰剂相比,利拉鲁肽对BMI(估计差异为-4.64%)和体重(绝对变化-4.50公斤,相对变化-5.01%)的降低幅度更大。利拉鲁肽组组胃肠道不良事件(64.8% vs 36.5%)和导致试验终止的不良事件(10.4% vs0)较多,但组间严重不良事件率较低。
 
在肥胖症青少年中,使用利拉鲁肽联合生活方式干预可显著降低患儿BMI。
 
原始出处:
 
Aaron S. Kelly et al. A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity. N Engl J Med, May 28, 2020.

 

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    2021-04-27 ms4000001291496338

    学习了

    0

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    2020-10-29 lovetcm

    #利拉鲁肽#治疗青少年#肥胖#,主要是使用仍然不方便

    0

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    2020-08-26 402753351

    中国还没有通过此类药物适用于减肥。

    0

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    2020-06-07 lovetcm

    儿童中不良事件相当多

    0

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    2020-05-28 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2020-05-28 lovetcm

    国内豪森长效GLP-1也许也可以🍋🍅

    0

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