Diabetologia：长期过度摄食对健康人骨骼肌线粒体的影响

2018-04-25 MedSci MedSci原创

在肥胖症和2型糖尿病中观察到骨骼肌线粒体能力降低。在人类中，这种异常的病因尚未得到很好的解释，但有学者建议，它可能是由于营养过剩的压力所导致的。为了验证这一假设，研究人员检查了持续过度摄食是否会减少骨骼肌线粒体含量或导致其功能损害。近日，国际杂志《Diabetologia》上在线发表一项关于长期过度摄食对健康人骨骼肌线粒体影响的研究。经过监督协议，26名健康志愿者（21名男性，5名女性

在肥胖症和2型糖尿病中观察到骨骼肌线粒体能力降低。在人类中，这种异常的病因尚未得到很好的解释，但有学者建议，它可能是由于营养过剩的压力所导致的。为了验证这一假设，研究人员检查了持续过度摄食是否会减少骨骼肌线粒体含量或导致其功能损害。近日，国际杂志《Diabetologia》上在线发表一项关于长期过度摄食对健康人骨骼肌线粒体影响的研究。经过监督协议，26名健康志愿者（21名男性，5名女性，年龄25.3±4.5岁，BMI 25.5±2.4 kg/m 2）接受了由8周高脂饮食（基线能量需求超过40％）。在过度摄食之前和之后，研究人员通过间接量热法测量系统物质氧化，并进行骨骼肌活检以测量体外线粒体基因表达，含量和功能。通过31 P NMR光谱法测量体内线粒体功能。研究发现，志愿者平均获得7.7±1.8公斤过度摄食量（％变化9.8±2.3）。过度摄食增加了空腹NEFA，LDL-胆固醇和胰岛素浓度。间接量热法显示出对脂质氧化依赖的转变。在骨骼肌组织中，过度摄食增加神经酰胺含量，脂滴含量和perilipin-2 mRNA表达。AMP活化蛋白激酶的磷酸化减少。某些编码线粒体蛋白基因（CS，OGD

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2019-02-02 ms9608593228839890

#DIA#

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2019-03-20 ms5439512287675881

#BET#

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2018-08-29 lishizhe

#健康人#

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2018-04-27 ms1065684921169360

#骨骼肌#

27 0
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2018-04-27 1209e435m98(暂无昵称)

学习了.谢谢分享

53 0
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2018-04-26 yfjms

学习

51 0
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2018-04-25 虈亣靌

不错.学习了.做笔记了.谢谢分享!

57 0

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