PLoS One:新型给药系统或可更好的治疗牙周炎

2017-10-31 MedSci MedSci原创

牙周炎是全球最常见的感染性疾病之一,如果不及时治疗,会导致牙齿支持组织的破坏,最终导致牙齿脱落。研究表明,标准治疗方法如根面平整,可通过进一步的辅助治疗,如局部应用药物,来提高治疗效果。由于龈沟液的存在,常常会冲刷掉牙周袋内的药物,因此研发合适有效的药物成了牙周病治疗的一个重要方向。本研究中,研究人员研发并检测了一种新的基于海藻酸钠的,可生物降解,且很容易适用于洗必泰(CHX)药物输送的系统。研究

牙周炎是全球最常见的感染性疾病之一,如果不及时治疗,会导致牙齿支持组织的破坏,最终导致牙齿脱落。研究表明,标准治疗方法如根面平整,可通过进一步的辅助治疗,如局部应用药物,来提高治疗效果。由于龈沟液的存在,常常会冲刷掉牙周袋内的药物,因此研发合适有效的药物成了牙周病治疗的一个重要方向。

本研究中,研究人员研发并检测了一种新的基于海藻酸钠的,可生物降解,且很容易适用于洗必泰(CHX)药物输送的系统。研究人员制备了不同的微珠,并负载了CHX,使用高效液相色谱法(HPLC)研究药物的释放曲线。

体外实验证明,CHX可从藻酸盐珠释放,其特点与临床应用的系统相似,但是这种新的药物输送系统的许多特性更有利于牙周治疗。可通过注射给药,应用方便,生产成本低,个性化用药可能会提高在牙周炎患者的常规护理。

原始出处:


Malte Scholz, Thomas Reske, et al., In vitro chlorhexidine release from alginate based microbeads for periodontal therapy. PLoS One. 2017; 12(10): e0185562. Published online 2017 Oct 3. doi: 10.1371/journal.pone.0185562

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1790059, encodeId=373a1e90059fc, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Aug 03 00:15:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450690, encodeId=3882145069067, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Thu Nov 02 12:15:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257641, encodeId=744325e64184, content=这个厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Nov 01 00:21:31 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257603, encodeId=792d25e603a6, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Oct 31 22:02:21 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257585, encodeId=78e525e585b9, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Oct 31 21:47:56 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1790059, encodeId=373a1e90059fc, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Aug 03 00:15:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450690, encodeId=3882145069067, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Thu Nov 02 12:15:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257641, encodeId=744325e64184, content=这个厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Nov 01 00:21:31 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257603, encodeId=792d25e603a6, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Oct 31 22:02:21 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257585, encodeId=78e525e585b9, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Oct 31 21:47:56 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-11-02 liuyong2982
  3. [GetPortalCommentsPageByObjectIdResponse(id=1790059, encodeId=373a1e90059fc, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Aug 03 00:15:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450690, encodeId=3882145069067, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Thu Nov 02 12:15:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257641, encodeId=744325e64184, content=这个厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Nov 01 00:21:31 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257603, encodeId=792d25e603a6, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Oct 31 22:02:21 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257585, encodeId=78e525e585b9, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Oct 31 21:47:56 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-11-01 飛歌

    这个厉害了我的哥

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1790059, encodeId=373a1e90059fc, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Aug 03 00:15:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450690, encodeId=3882145069067, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Thu Nov 02 12:15:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257641, encodeId=744325e64184, content=这个厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Nov 01 00:21:31 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257603, encodeId=792d25e603a6, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Oct 31 22:02:21 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257585, encodeId=78e525e585b9, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Oct 31 21:47:56 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-10-31 惠映实验室

    学习了.谢谢

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1790059, encodeId=373a1e90059fc, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Aug 03 00:15:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450690, encodeId=3882145069067, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Thu Nov 02 12:15:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257641, encodeId=744325e64184, content=这个厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Nov 01 00:21:31 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257603, encodeId=792d25e603a6, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Oct 31 22:02:21 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257585, encodeId=78e525e585b9, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Oct 31 21:47:56 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-10-31 thlabcde

    好资料学习了!

    0

相关资讯

研究进一步揭示肥胖与牙周炎关联的潜在机制

世界范围内,肥胖症是非常普遍的慢性疾病,可增加牙周炎的易感性。本文旨在提供肥胖与牙周病之间关联的系统评价,并确定这种关系的潜在的机制。研究人员检索了PubMed-Medline和Embase数据库中相关文祥,选择对照临床试验和观察性研究,确定牙周和身体组成参数。对每篇文章都进行了数据提取和质量评估。结果共检索了284篇相关文章,预选纳入其中64篇,最终纳入28篇文献进行审查。除了两篇文章显示没有关

J Periodontal Res:虾青素可通过增加成骨细胞活性并降低破骨细胞活性来对抗牙周炎

虾青素是具有很强抗氧化作用的酮类胡萝卜素。本研究旨在评估虾青素对结扎诱导的牙周炎大鼠牙槽骨丢失和组织病理学变化的影响。将Wistar大鼠分为4个实验组:未结扎(C,n = 6);仅结扎(L,n = 6);结扎和虾青素(1mg/kg/天虾青素,AS1组,n = 8);结扎和虾青素(5mg/kg/天虾青素,AS5组,n = 8)。丝线结扎部位为下颌第一磨牙。研究时间为11天,结束后处死大鼠。临床评估牙

J Clin Periodontol:至少存在三种表型的牙周炎

通过使用无人监督的建模技术(分类),基于预处理放射学和微生物特征来鉴定牙周炎患者的表型。

J Clin Periodontol:慢性牙周炎与血小板因子4(PF4)分泌相关

血小板与慢性炎症相关,但它们在牙周炎中的作用尚不清楚。本研究的目的是比较健康和炎性牙周组织中的血小板募集和激活。

J Clin Periodontol:kava-241抑制胶原抗体引发的牙周破坏

这项研究的目的是评估Kava-241,一种优化的Piper methysticum Kava复合物对胶原蛋白抗体引发的牙周破坏的影响。

J Clin Periodontol:垂直分型预测II类磨牙根分叉病变的存留

根分叉病变是牙齿存留的主要预测因素。而目前的焦点在于根分叉病变的水平分量的预测价值。每个牙的剩余牙周支持可能在保留根分叉磨牙上起主要作用。这项临床研究的目的是初步评估垂直分类对牙齿保留的影响。