JAHA:国人学者揭示抑郁可增加心梗患者不良预后风险

2019-02-27 不详 MedSci原创

非阻塞性冠脉心梗(MINOCA)占到心梗患者的约10%,目前尚缺乏抑郁对MINOCA预后影响的研究。本研究的目的旨在评估抑郁对中国MINOCA患者预后的影响。本研究纳入了633例MINOCA患者,并随访了3年,终点事件为全因死亡率和心血管事件。在随访期间,有93例患者发生全因死亡事件,170例患者发生不良心血管事件。 Kaplan-Meier 曲线结果显示抑郁与全因死亡率和心血管事件均呈明显相关性

非阻塞性冠脉心梗(MINOCA)占到心梗患者的约10%,目前尚缺乏抑郁对MINOCA预后影响的研究。本研究的目的旨在评估抑郁对中国MINOCA患者预后的影响。

本研究纳入了633例MINOCA患者,并随访了3年,终点事件为全因死亡率和血管事件。在随访期间,有93例患者发生全因死亡事件,170例患者发生不良血管事件。 Kaplan-Meier 曲线结果显示抑郁与全因死亡率和心血管事件均呈明显相关性(log-rank P<0.001)。多元回归分析发现新发的抑郁是全因死亡和心血管事件的独立预测因子(HR:7.250; 95% CI, 4.735–11.100; P<0.001; HR: 3.411; 95% CI, 2.490–4.674; P<0.001)。

研究结果显示,对于非阻塞性冠脉心梗患者,心梗后新发的抑郁与不良预后呈明显相关性。

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    2019-03-01 zhaohui6731
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    2019-02-28 1dd8a7c5m95(暂无匿称)

    好文章,点赞啦!认真学习,谢谢分享给广大同好!

    0

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    2019-02-27 飛歌

    学习了很有用不错

    0

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蒽环霉素引起的心脏毒性是一个重要的临床问题,然而尚缺乏早期预测蒽环霉素引起的心脏毒性的标志物。本研究的目的旨在动物实验中通过连续多参数心脏磁共振(CMR)来评估阿霉素引起的心脏毒性。 本研究纳入了20只实验猪,其中5只接受了5次两周一次的冠脉内阿霉素的输注(0.45 mg/kg),随访16周;5只接受了3次两周一次的冠脉内阿霉素的输注,随访16周,第三组动物在第三次给药后被处死。所有动物