东亚地区锁骨肿瘤回顾性荟萃分析

2013-04-26 Flower整理 医学论坛网

  近日由任可等发表于《肿瘤防治研究》上的一项回顾性荟萃分析提示,锁骨肿瘤和肿瘤样病变的分布具有年龄和性别倾向性。在东亚地区人群中,嗜酸性肉芽肿和来源于骨髓造血系统的肿瘤所占的构成比相对较高,高龄是锁骨恶性肿瘤的危险因素。这些特点可能与锁骨的组织结构和发育方式以及蒙古利亚人种的遗传学特征有关。   该研究的目的是总结东亚地区锁骨原发性肿瘤和肿瘤样病变的临床、病理及流行病学特点。   研究者检索

  近日由任可等发表于《肿瘤防治研究》上的一项回顾性荟萃分析提示,锁骨肿瘤和肿瘤样病变的分布具有年龄和性别倾向性。在东亚地区人群中,嗜酸性肉芽肿和来源于骨髓造血系统的肿瘤所占的构成比相对较高,高龄是锁骨恶性肿瘤的危险因素。这些特点可能与锁骨的组织结构和发育方式以及蒙古利亚人种的遗传学特征有关。

  该研究的目的是总结东亚地区锁骨原发性肿瘤和肿瘤样病变的临床、病理及流行病学特点。

  研究者检索1980—2011年期间东亚国家公开发表的有关锁骨原发性肿瘤和肿瘤样病变的文献,并进行荟萃分析。

  结果纳入病例222例,年龄1.5~70岁,平均年龄29.4岁。性别比例:男∶女为1.53∶1。病灶部位:局限于内、中、外1/3段者分别为28.9%、18.8%和33.6%,同时累及内侧和中央1/3和同时累及中央和外侧1/3者均为7.4%,累及全长者4.0%。主要病理类型:嗜酸性肉芽肿18.02%,浆细胞瘤9.91%,骨肉瘤和骨软骨瘤8.11%,尤文肉瘤7.21%,软骨肉瘤5.41%。10岁以下恶性肿瘤少见,而40岁以上恶性肿瘤比率明显增加,说明肿瘤的良恶性比率与发病年龄的相关关系显著。瘤段切除手术为主要的治疗方式,其中40.8%的病例采用了自体或异体骨移植重建。



    

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