Chin Circ J:陕西学者研究称,尼可地尔治疗心脏X综合征有效

2017-08-16 朱柳媛 中国循环杂志

近期,陕西中医药大学第二附属医院贺学魁等在本刊发文报告,具有类硝酸酯和钾离子通道激动特性的双重作用机制的尼可地尔对这类患者有较好疗效。

临床上,有一类患者有很典型的心绞痛症状,做心电图或平板运动试验阳性,但冠状动脉造影正常,没有冠状动脉痉挛。这类患者叫做心脏X综合征患者。

目前用来治疗心脏X综合征的药物主要包括硝酸酯类、β 受体阻滞剂和钙拮抗剂,但效果并不理想。

近期,陕西中医药大学第二附属医院贺学魁等在本刊发文报告,具有类硝酸酯和钾离子通道激动特性的双重作用机制的尼可地尔对这类患者有较好疗效。

研究显示,心脏X综合征患者在常规抗心绞痛药物治疗基础上,加用尼可地尔治疗3个月后,心绞痛发作频率、心肌核素扫描(ECT)阳性率、心电图平板运动试验可疑阳性率及阳性率均明显下降。

与仅用常规抗心绞痛药物的患者相比,加用尼可地尔的患者3个月后心电图平板运动试验可疑阳性率及阳性率也明显降低。

研究者进一步发现,尼可地尔是通过抑制炎症因子、改善血管内皮功能机制发挥作用的。

加用尼可地尔的患者治疗3个月后,血浆内皮素、血清高敏C反应蛋白水平降低,而一氧化氮水平升高,与仅用常规抗心绞痛药物的患者相比也有明显差异。

原始出处:贺学魁,董静,赵运,等. 尼可地尔对心脏X综合征的疗效及对血管内皮功能的影响. 中国循环杂志, 2017, 32: 676-679.

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    2017-08-16 1e0f8808m18(暂无匿称)

    尼可地尔治疗心脏X综合征效果好。

    0

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    2017-08-16 惠映实验室

    学习了,谢谢。

    0