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Biomaterials：利用巨噬细胞介导的降解明胶微球可更好的改善骨愈合

2018-03-16 MedSci MedSci原创

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基于生物材料利用免疫和炎症反应的方法来来加强伤口愈合具有重要的前景。骨折愈合的特征是急性炎症阶段，随后转变为再生和修复阶段。在这项研究中，我们开发了genipin交联明胶微球，旨在优先被炎症（M1）巨噬细胞降解。 通过静电相互作用高度交联（> 90％）的微球可有效与生物活性骨形态发生蛋白2（BMP2）整合。BMP2的释放与明胶基质的降解直接相关。微球暴露于极化的小鼠巨噬细胞显示，与交替

基于生物材料利用免疫和炎症反应的方法来来加强伤口愈合具有重要的前景。骨折愈合的特征是急性炎症阶段，随后转变为再生和修复阶段。在这项研究中，我们开发了genipin交联明胶微球，旨在优先被炎症（M1）巨噬细胞降解。

通过静电相互作用高度交联（> 90％）的微球可有效与生物活性骨形态发生蛋白2（BMP2）整合。BMP2的释放与明胶基质的降解直接相关。微球暴露于极化的小鼠巨噬细胞显示，与交替激活的（M2）巨噬细胞和非极化对照巨噬细胞相比，M1巨噬细胞的降解更高。

在非炎性细胞存在下的微球降解导致非常低的降解速率。巨噬细胞表达基质金属蛋白酶（MMPs）和基质金属蛋白酶组织抑制剂（TIMPs）与观察到的表型依赖性降解速率一致。负载BMP2的微球和巨噬细胞与分离的脂肪来源的间充质干细胞（MSC）的间接共培养显示，M1巨噬细胞产生最强的成骨反应，与伴有BMP2的直接补充培养基相当。

综上所述 ，该研究结果表明，与炎症反应同步的控制释放系统有可能更好的控制生长因子的释放，因此可以改善顽固性伤口的愈合。

原始出处：

Annamalai RT, Turner PA, et al., Harnessing macrophage-mediated degradation of gelatin microspheres for spatiotemporal control of BMP2 release. Biomaterials. 2018 Apr;161:216-227. doi: 10.1016/j.biomaterials.2018.01.040. Epub 2018 Feb 3.

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    2019-01-29 sunylz

    #Bio#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1917976, encodeId=95f9191e97655, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jan 29 07:53:00 CST 2019, time=2019-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049994, encodeId=5aa8204999405, content=<a href='/topic/show?id=cbdd3451e3' target=_blank style='color:#2F92EE;'>#Biomaterials#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3451, encryptionId=cbdd3451e3, topicName=Biomaterials)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e0333, createdName=zhangyxzsh, createdTime=Tue Apr 17 22:53:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026980, encodeId=292e2026980a7, content=<a href='/topic/show?id=921d101668c8' target=_blank style='color:#2F92EE;'>#骨愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101668, encryptionId=921d101668c8, topicName=骨愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Fri Oct 05 08:53:00 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296972, encodeId=f3fd2969e2a7, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Mar 17 05:04:59 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-04-17 zhangyxzsh

    #Biomaterials#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1917976, encodeId=95f9191e97655, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jan 29 07:53:00 CST 2019, time=2019-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049994, encodeId=5aa8204999405, content=<a href='/topic/show?id=cbdd3451e3' target=_blank style='color:#2F92EE;'>#Biomaterials#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3451, encryptionId=cbdd3451e3, topicName=Biomaterials)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e0333, createdName=zhangyxzsh, createdTime=Tue Apr 17 22:53:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026980, encodeId=292e2026980a7, content=<a href='/topic/show?id=921d101668c8' target=_blank style='color:#2F92EE;'>#骨愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101668, encryptionId=921d101668c8, topicName=骨愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Fri Oct 05 08:53:00 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296972, encodeId=f3fd2969e2a7, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Mar 17 05:04:59 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-10-05 redcrab

    #骨愈合#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1917976, encodeId=95f9191e97655, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jan 29 07:53:00 CST 2019, time=2019-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049994, encodeId=5aa8204999405, content=<a href='/topic/show?id=cbdd3451e3' target=_blank style='color:#2F92EE;'>#Biomaterials#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3451, encryptionId=cbdd3451e3, topicName=Biomaterials)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e0333, createdName=zhangyxzsh, createdTime=Tue Apr 17 22:53:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026980, encodeId=292e2026980a7, content=<a href='/topic/show?id=921d101668c8' target=_blank style='color:#2F92EE;'>#骨愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101668, encryptionId=921d101668c8, topicName=骨愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Fri Oct 05 08:53:00 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296972, encodeId=f3fd2969e2a7, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Mar 17 05:04:59 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-17 changjiu

    学习一下谢谢

    0