Cancer Cell:中国癌症研究进展

2011-12-05 MedSci原创 MedSci原创

 “中国是最大的发展中国家,经历了快速的工业化,城市化,和市场经济化。这些社会变革导致了一些不良后果,比如生态恶化,环境污染,这些都是癌症的诱发因素。除此之外,我们还有大约3亿的烟民,超过9千万的乙肝患者……” ——陈竺 著名癌症研究国际期刊Cancer Cell杂志最新推出了一份增刊:Spotlight on China,主要聚焦于中国目前癌症研究和治疗方面的进展,并介绍了国

 “中国是最大的发展中国家,经历了快速的工业化,城市化,和市场经济化。这些社会变革导致了一些不良后果,比如生态恶化,环境污染,这些都是癌症的诱发因素。除此之外,我们还有大约3亿的烟民,超过9千万的乙肝患者……”

——陈竺

著名癌症研究国际期刊Cancer Cell杂志最新推出了一份增刊:Spotlight on China,主要聚焦于中国目前癌症研究和治疗方面的进展,并介绍了国内8所癌症研究领先研究所,以及生物医药技术企业,除此之外,卫生部部长陈竺发表了题为“The China Front on the War against Cancer”评论。(全文阅读

Cancer Cell增刊封面
(Cancer Cell增刊封面,由苏华教授(音译)题字)
人类与癌症的“拉锯战”进行多年,并且近年来随着老龄化的加剧,癌症的发生率以及死亡率都在急剧攀升,这使得癌症研究变得更加迫切。

中国在癌症研究与治疗课题项目上的投入逐年增长,并且也取得了不少重要的成果,令人侧目。Cancer Cell杂志此次就聚焦了这一领域,捕捉中国在癌症研究和治疗方面的进展。相关文章介绍了国内如何利用各种新型技术推进科研发展,这些技术包括基因组学技术,代谢组学,靶向治疗,还有分析miRNAs,代谢产物和循环肿瘤细胞,在癌症代谢和遗传学中扮演的重要角色,以及在癌症早期检测,治疗过程中的潜在生物标记物作用。

增刊中也提及了中国科学家和临床医师在控制乙肝病毒传播,降低肝癌患病率方面的努力,除此之外,随着乳腺癌的发生率增长,科学家们认为发展诊断和治疗的技术也迫在眉睫,我们也需要更深入的了解乳腺癌的发生机制。

最后这一专辑逐一介绍了国内8所癌症研究领先研究所:中国医学科学院/北京协和医学院、中国抗癌协和(CSCO)、中山大学、复旦大学、北京大学肿瘤医院、上海血液学研究所、清华大学和香港中文大学,以及国内的生物医药和生物技术企业。

今年国内的科学家在癌症研究方面,确实取得了不少成果,尤其是在癌症研究组学研究领域,我国2006年就发布了中国癌症基因组的初步蓝图,2008年正式加入国际癌症基因组计划学会,近年来取得了多项成果,比如今年中国医学科学院/北京协和医学院的研究人员通过全基因组关联研究发现了多个全新的中国人群食管鳞状细胞癌(Esophageal squamous cell carcinoma ,ESCC)易感位点,这对于解析这一疾病的分子机理,以及相关治疗具有重要意义,生物通就此进行了详细报道专访林东昕:食管癌全基因组关联研究。

另外在肝癌研究方面,上半年上海生科院的研究人员分析了一种关键肝癌治疗药物在早期肝癌治疗中的作用,为将索拉菲尼应用于早期肝癌的治疗(尤其是早期肝癌术后治疗)提供了有力的实验依据。近期复旦大学的研究人员又在肝癌早期诊断方面的研究取得新突破:找到比甲胎蛋白更准确“预报”肝癌的血液生物分子标志物。这种检测方法对小于2cm的肝癌诊断准确率接近90%,效果优于传统检测方法。

这些成果都将进一步推进我国癌症研究和治疗事业的发展,相信随着研究的逐步深入,我们将最终揭开癌症神秘的面纱。
 
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    2012-02-25 维他命
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