J Surg Oncol:根治性前列腺切除术后尿失禁修复术的全国性的和基于人群的研究

2017-09-12 AlexYang MedSci原创

最近,有研究人员进行了旨在评估根治性前列腺切除术(RP)后尿失禁(PPI)手术的使用情况和调查了该手术使用相关的因素。群体研究是在瑞典男性前列腺癌数据库(PCBaSe)中进行的,这些病人是在1998年和2012年年间进行初次的RP。PPI修正术过程在病人注册处进行鉴定。另外,研究人员还评估了PPI外科手术的风险比(HR)和95%的置信区间(CIs)。研究发现,26280名男性中的782名(3%)男

最近,有研究人员进行了旨在评估根治性前列腺切除术(RP)后尿失禁(PPI)手术的使用情况和调查了该手术使用相关的因素。群体研究是在瑞典男性前列腺癌数据库(PCBaSe)中进行的,这些病人是在1998年和2012年年间进行初次的RP。PPI修正术过程在病人注册处进行鉴定。另外,研究人员还评估了PPI外科手术的风险比(HR)和95%的置信区间(CIs)。研究发现,26280名男性中的782名(3%)男性患者在RP后平均3年时间后进行了PPI手术。在2000年到2014年,PPI手术的绝对值增加了8倍,并且在每1000RPs中,PPI手术增加了3倍。PPI手术的高度使用相关因素为年龄大于70岁,HR为1.96(1.54-2.50),以及高RP容量(>100 RPs每年),HR为0.81(0.66-0.99)。另外,在每1000 RPs中,最高使用地区和最低使用地区在PPI手术的使用上具有10倍的差异。在病人报道的结果测量(PROM)男性亚群中,7%的男性报道了重度PPI,并且他们中的24%经历了PPI手术。最后,研究人员指出,所有男性中的3%接受了PPI手术,卫生服务提供者之间也具有1

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    2017-10-15 minlingfeng
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    2017-09-14 jeanqiuqiu
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    2017-09-13 执着追梦

    学习.谢谢分享

    0

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越来越多的研究表明长非编码RNAs(lncRNAs)在肿瘤形成和癌症恶化中起着重要作用。来源于ZEB1启动子区域的lncRNA ZEB1 反义1(ZEB1-AS1)到现在为止,人们对其表达、作用和机制所知甚少。最近,有研究人员利用RACE技术获得了ZEB1-AS1的序列,并利用RNA干扰技术减少ZEB1-AS1的表达,还利用腺病毒表达载体来增加ZEB1-AS1的表达。另外,研究人员利用CHIP和R

Nat Commun:前列腺癌中雄激素受体信号途径和PARP通路之间的合成致死作用

最近,来自英国剑桥大学癌症研究中心的一项研究表明,前列腺癌中雄激素受体信号途径和PARP通路之间具有合成致死作用。越来越多的数据阐释了同源重组(HR)在去势难治性前列腺癌中的缺陷,致使这些肿瘤对PARP抑制作用表现为敏感。最近,研究人员阐明了雄激素受体(AR)来维持HR基因的表达和在前列腺癌中HR活性的直接需求。研究发现,在雄激素阻断治疗(ADT)后,PARP调控的修复通路在前列腺癌中表达上调。更

Am J Transl Res:或可通过靶向miR-204/ZEB1治疗晚期/耐药前列腺癌患者

microRNAs (miRNAs)所致的表观基因失活在肿瘤恶性转化、防止凋亡、耐药性和转移中起着至关重要的作用。研究已经发现前列腺癌(PC)中miR-204的表达失调,且认为miR-204与肿瘤耐药性的发生相关。然而,miR-204在PC中发挥作用的详细机制,特别是耐药性,尚未完全阐明。本研究中,研究人员利用miRNA微阵列分析发现,与药物敏感的PC组织及良性前列腺增生组织中相比,耐药PC组织中

BMC Urol:亚洲前列腺癌双周、减少剂量多烯紫杉醇的回顾可行性研究

最近,有研究人员评估了在韩国患有去势难治性前列腺癌(CRPC)病人中,多烯紫杉醇减少剂量和双周频次化疗的临床结果。研究人员回顾性的评估了48名患有转移CRPC病人的医疗记录,这些病人接受过两周一次频率(在第1天静脉注射多烯紫杉醇40mg/m2,另加每日两次的5mg氢化波尼松),时间为2012年到2015年,地点在三星医疗中心(韩城,韩国)。在2013年10月进行双周次频率之前,24名患有CRPC病