JCEM:中国老年人血糖测量与死亡风险

2019-11-03 xing.T MedSci原创

由此可见,负荷后2h血糖较高的个体比正常血糖的个体死亡风险高43%。OGTT的使用不足会导致较高死亡风险的个体未被发现,并且早期干预的机会会大大减少。

中国是世界上拥有2型糖尿病(T2DM)人数最多的国家。先前研究的数据表明,如果不进行口服葡萄糖耐量测试(OGTT),五分之一的糖尿病患者将被遗漏。迄今为止,关于这些人的死亡风险的信息很少。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在估计中国普通人群高血糖症不同指标与死亡率之间的关系。

该研究为前瞻性队列研究,参与者为17939名50岁以上的之前诊断糖尿病以及新发糖尿病患者,血糖(≥7.0mmol/L),负荷后2小时葡萄糖(≥11.1mmol/L)或血红蛋白A1c(HbA1c,≥6.5%)。该研究的主要结果指标为通过联系死亡登记中心确定的全因、心血管疾病和癌症死亡情况。

在7.8年(标准差=1.5)的随访中,共记录了1439例死亡患者。在3706名患有T2DM的参与者中,有2126名(57%)参与者知道T2DM,通过单一空腹血糖升高发现了118名(3%)T2DM,有1022人(28%)通过负荷后血糖升高确定了T2DM,而440人(12%)空腹和后负荷葡萄糖均有升高。与正常血糖相比,上述四组全因死亡率的HR(95%CI)分别为1.71(1.46-2.00)、0.96(0.47-1.93)、1.43(1.15-1.78)和1.82(1.35-2.45)。HbA1c升高定义的T2DM与全因死亡率没有显著相关性(HR为1.17,95%CI为0.81-1.69)。

由此可见,负荷后2h血糖较高的个体比正常血糖的个体死亡风险高43%。OGTT的使用不足会导致较高死亡风险的个体未被发现,并且早期干预的机会会大大减少。 

原始出处:

Chao Qiang Jiang,et al.Glycaemic measures and risk of mortality in older Chinese: the Guangzhou Biobank Cohort Study.J Clin Endocrinol Metab.2019.https://doi.org/10.1210/clinem/dgz173

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2063283, encodeId=b49d20632831b, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Aug 01 23:16:00 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777901, encodeId=e0a61e77901f7, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sat Jan 11 12:16:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255916, encodeId=c095125591638, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Nov 05 03:16:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374757, encodeId=bacc3e475778, content=规律监测血糖,对血糖有指导,使血糖尽量做到达标,减少并发症的发生。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1365220136, createdName=1477a62dm45暂无昵称, createdTime=Sun Nov 03 16:27:42 CST 2019, time=2019-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374752, encodeId=eaa73e4752c0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Nov 03 13:32:58 CST 2019, time=2019-11-03, status=1, ipAttribution=)]
    2020-08-01 achengzhao
  2. [GetPortalCommentsPageByObjectIdResponse(id=2063283, encodeId=b49d20632831b, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Aug 01 23:16:00 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777901, encodeId=e0a61e77901f7, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sat Jan 11 12:16:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255916, encodeId=c095125591638, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Nov 05 03:16:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374757, encodeId=bacc3e475778, content=规律监测血糖,对血糖有指导,使血糖尽量做到达标,减少并发症的发生。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1365220136, createdName=1477a62dm45暂无昵称, createdTime=Sun Nov 03 16:27:42 CST 2019, time=2019-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374752, encodeId=eaa73e4752c0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Nov 03 13:32:58 CST 2019, time=2019-11-03, status=1, ipAttribution=)]
    2020-01-11 smallant2015
  3. [GetPortalCommentsPageByObjectIdResponse(id=2063283, encodeId=b49d20632831b, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Aug 01 23:16:00 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777901, encodeId=e0a61e77901f7, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sat Jan 11 12:16:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255916, encodeId=c095125591638, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Nov 05 03:16:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374757, encodeId=bacc3e475778, content=规律监测血糖,对血糖有指导,使血糖尽量做到达标,减少并发症的发生。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1365220136, createdName=1477a62dm45暂无昵称, createdTime=Sun Nov 03 16:27:42 CST 2019, time=2019-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374752, encodeId=eaa73e4752c0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Nov 03 13:32:58 CST 2019, time=2019-11-03, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2063283, encodeId=b49d20632831b, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Aug 01 23:16:00 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777901, encodeId=e0a61e77901f7, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sat Jan 11 12:16:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255916, encodeId=c095125591638, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Nov 05 03:16:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374757, encodeId=bacc3e475778, content=规律监测血糖,对血糖有指导,使血糖尽量做到达标,减少并发症的发生。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1365220136, createdName=1477a62dm45暂无昵称, createdTime=Sun Nov 03 16:27:42 CST 2019, time=2019-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374752, encodeId=eaa73e4752c0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Nov 03 13:32:58 CST 2019, time=2019-11-03, status=1, ipAttribution=)]
    2019-11-03 1477a62dm45暂无昵称

    规律监测血糖,对血糖有指导,使血糖尽量做到达标,减少并发症的发生。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2063283, encodeId=b49d20632831b, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Aug 01 23:16:00 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777901, encodeId=e0a61e77901f7, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sat Jan 11 12:16:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255916, encodeId=c095125591638, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Nov 05 03:16:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374757, encodeId=bacc3e475778, content=规律监测血糖,对血糖有指导,使血糖尽量做到达标,减少并发症的发生。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1365220136, createdName=1477a62dm45暂无昵称, createdTime=Sun Nov 03 16:27:42 CST 2019, time=2019-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374752, encodeId=eaa73e4752c0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Nov 03 13:32:58 CST 2019, time=2019-11-03, status=1, ipAttribution=)]
    2019-11-03 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

相关资讯

Clinica Chimica Acta:中国抗磷脂综合征患者非标准抗体的临床表现

越来越多的证据表明,非标准aPLs可在APS中作为现行标准aPLs的重要补充。在本研究中,研究人员评估了一组对磷脂抗原的非标准抗体,包括磷脂酰丝氨酸(aPS)、磷脂酰肌醇(aPI)、鞘磷脂(aSM)、磷脂酰胆碱(aPC)和磷脂酰乙醇胺(aPE)在明确的中国aPS队列中的临床表现。

Clinica Chimica Acta:中国急性冠状动脉综合征患者非高密度脂蛋白胆固醇的目标需要调整:CCC-ACS项目的研究结果

指南建议将非高密度脂蛋白胆固醇(non-HDL-C)作为共同主要目标,并将非HDL-C目标设置为比低密度脂蛋白胆固醇(LDL-C)目标高30 µmg / dl。但在中国患者中,这一价值在很大程度上是不确定的。

European Journal of Human Genetics:中国SNHL患者的综合遗传测试和变异解释

遗传性听力损失是一种单基因遗传病,并且具有高度的异质性。不少于100个耳聋基因在病理发生过程中具有作用。最近,有研究人员评估了SNVs在已知的耳聋基因中的比例,从而对中国散发性和家族性感感觉神经性耳聋患者的病因进行解释。研究人员手搜集了1127名个体的DNA样本,包括616名正常听力的健康对照,433名散发性SNHL患者和来源于30个听力损失谱系的78名耳聋患者。NGS测试包括了129个基因中的序

着力构建新型卫生健康服务体系 服务健康中国建设

新中国走过了70年的光辉历程,创造了无数人间奇迹,取得了举世瞩目的巨大成就,人民健康水平也得到了显着提高。到2018年,我国居民人均期望寿命接近77岁,婴儿死亡率、孕产妇死亡率分别下降到6.1/‰、18.3/10万,达到或接近中高收入国家水平。经过几十年的建设和发展,我国建立了与经济社会发展水平和人民群众日益增长健康需求比较适应、世界上规模最大、水平较高的卫生健康服务体系,在保障人民健康的伟大

Heart:中国东北地区房颤的流行病学特征

由此可见,东北地区的AF负担巨大,OAC治疗的未充分使用和合并症未能有效控制可能会在未来几十年中加剧AF患者的心血管结局。对于东北地区急需AF及相关危险因素长期管理的策略。

提出中国高血压防控的四个独特方法:在公共场所建立可与微信链接的血压计,每年测量数千万人

上海交通大学医学院附属瑞金医院王继光教授介绍了中国高血压防控的独特途径。根据中国2012-2015年度全国高血压调查,成人高血压患病率为27.9%,较2002(18.8%)增加50%。高血压的知晓率、治疗率和控制率分别为46.9%、40.7%和15.3%。王继光指出,我国的高血压的管理水平有所提高,但仍处于较低水平,我国高血压管理面临的挑战仍然是低知晓率和低控制率。