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Acta Biomater：基于胶原的纳米膜组成的人工细胞纳米环境可促进间充质干细胞的成骨分化

2019-01-09 MedSci MedSci原创

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在再生医学中，治疗性干细胞和组织工程的产生对于替换受损组织是重要的。许多研究已经尝试产生模拟天然组织以获得最佳功能的细胞组分。特别地，细胞外基质（ECM）组合物在细胞功能中起重要作用，包括确定间充质干细胞（MSC）的转化。在这里，我们评估了纳米薄膜的成骨作用，其中带相反电荷的聚电解质交替吸附在细胞表面上，为单个MSC创造了一个人工ECM环境。有趣的是，由胶原蛋白（Col）和藻酸盐（AA）组成的纳米

在再生医学中，治疗性干细胞和组织工程的产生对于替换受损组织是重要的。许多研究已经尝试产生模拟天然组织以获得最佳功能的细胞组分。特别地，细胞外基质（ECM）组合物在细胞功能中起重要作用，包括确定间充质干细胞（MSC）的转化。

在这里，我们评估了纳米薄膜的成骨作用，其中带相反电荷的聚电解质交替吸附在细胞表面上，为单个MSC创造了一个人工ECM环境。有趣的是，由胶原蛋白（Col）和藻酸盐（AA）组成的纳米膜显示出相对高的硬度，并且与其他纳米膜包被的MSC相比，用Col/AA纳米膜包被的MSCs显示出更好的成骨分化效率。进一步的分析表明，Col/AA纳米薄膜涂层通过激活具有PDZ结合基序的转录共激活因子通过细胞外信号相关激酶和p38 MAPK信号传导来刺激成骨。

总之，该研究结果表明，这种纳米级细胞涂层将促进纳米技术的发展，以控制细胞功能，并推进基于干细胞的再生医学临床应用。

原始出处：

Hwang JH, Han U, et al., Artificial cellular nano-environment composed of collagen-based nanofilm promotes osteogenic differentiation of mesenchymal stem cells. Acta Biomater. 2018 Dec 27. pii: S1742-7061(18)30769-4. doi: 10.1016/j.actbio.2018.12.044. 

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    2019-08-17 windight

    #CTA#

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    2019-04-19 sunylz

    #Bio#

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    2019-10-10 h.y200607_23674418

    #间充质干细#

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    2019-12-05 HinsMax

    #骨分化#

    0

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    2019-01-11 ms5880526374914242

    #成骨分化#

    0

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    2019-01-11 zhaojie88

    #成骨#

    0