NEJM:VE醋酸酯或是电子烟相关性肺损伤致病因素

2020-02-20 MedSci MedSci原创

维生素E醋酸酯或可导致电子烟相关性肺损伤

电子烟相关性肺损伤(EVALI)的致病因素尚未确定,近日研究人员采集EVALI患者支气管肺泡灌洗液(BAL)进行毒物检测以获取EVALI的直接信息。

近日,研究人员收集了16个州,51名EVALI患者和99名健康参与者BAL洗液,采用同位素稀释质谱法测定维生素E醋酸酯、植物油、中链甘油三酯油、椰子油、石油馏分油和稀释剂萜烯的含量。

51名患者中,25例为确诊病例,26例为疑似EVALI病例。所有患者中,48例(94%)患者的BAL液中发现了维生素E醋酸酯,而健康对照组的BAL液中未检出维生素E乙酸酯。除椰子油和柠檬烯(各组均1例),未发现其他毒物。在有实验室或流行病学数据的病例中,50人中有47人(94%)在BAL液中检测到四氢大麻酚(THC)或其代谢物或在发病前90天内吸入含THC物质,47例患者中有30例(64%)检测到尼古丁及其代谢物。

研究认为,维生素E醋酸酯或可导致电子烟相关性肺损伤。

原始出处:

Benjamin C. Blount et al. Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI. N Engl J Med, February 16, 2020.

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    2020-02-22 tastas
  6. [GetPortalCommentsPageByObjectIdResponse(id=1946059, encodeId=f601194605970, content=<a href='/topic/show?id=bef9864e4e4' target=_blank style='color:#2F92EE;'>#致病因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86474, encryptionId=bef9864e4e4, topicName=致病因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b1f500, createdName=zengjiayao, createdTime=Sun Mar 22 16:29:00 CST 2020, time=2020-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837796, encodeId=d69e183e79667, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Jul 24 02:29:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986247, encodeId=eb7f198624e52, content=<a href='/topic/show?id=a7a6e0071d6' target=_blank style='color:#2F92EE;'>#电子烟相关性肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70071, encryptionId=a7a6e0071d6, topicName=电子烟相关性肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Dec 14 06:29:00 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397914, encodeId=04fa139e91401, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Feb 22 09:29:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503325, encodeId=d26a1503325f3, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Sat Feb 22 09:29:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035142, encodeId=17171035142fd, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 20 21:29:00 CST 2020, time=2020-02-20, status=1, ipAttribution=)]
    2020-02-20 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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