急性肝衰竭儿科辛存者生活质量研究

2016-11-14 MedSci MedSci原创

2016年肝病会议上呈现的研究数据显示,急性肝衰竭后的儿童和青少年辛存者,在执行能力、运动技能和健康相关生活质量(HRQOL)方面存在不足。 来自芝加哥Ann & Robert H. Lurie儿童医院精神病学和行为科学部门的Lisa G. Sorensen博士说:“这些发现与先前公布的横断面研究一致。” 在这个多中心的研究中,Sorensen及其同事评估了158例急性肝衰竭后

2016年肝病会议上呈现的研究数据显示,急性肝衰竭后的儿童和青少年辛存者,在执行能力、运动技能和健康相关生活质量(HRQOL)方面存在不足。

来自芝加哥Ann & Robert H. Lurie儿童医院精神病学和行为科学部门的Lisa G. Sorensen博士说:“这些发现与先前公布的横断面研究一致。”

在这个多中心的研究中,Sorensen及其同事评估了158例急性肝衰竭后的儿童和青少年辛存者(PALF)。纳入研究后6个月和12个月,对2-16岁患儿进行了执行能力研究,对2-19岁患儿进行了生活质量调查。

Sorensen说:“这项研究的目的是,比较PALF辛存者和健康对照组的HRQOL差异,评估PALF辛存者的神经认知障碍的患病率。”

对照组包括828名健康儿童。

共25例患者完成了神经认知测试,6个月时,52例有家长报告的HRQOL数据,1年时,43例有家长报告的HRQOL数据。这些患者中,完成神经认知测试的44%、完成HRQOL的48%的患者有不确定的病因;完成神经认知测试的22%、完成HRQOL的21%的患者有3级或4级肝性脑病;完成神经认知测试的52%、完成HRQOL的50%的患者进行了肝移植。

Beery VMI-6运动协调(平均:85.1±15.2)和视觉运动整合(平均:90.3±14.1)低于正常水平(P值均 < .001),而韦氏量表中的全面智商和康纳斯连续性能测试中的注意力方面,没有低于正常水平。

Sorensen说:“PALF患者与健康对照组相比,6个月和12个月的HRQOL更差,最差的是12个月时的自我报告结局。”

“PALF辛存者在随后6个月和12个月时,患者和父母报告了显著更高水平的疲劳,包括认知疲劳。”

单因素分析显示,年龄、父母教育、肝移植、肝性脑病,是任何水平肝性脑病或运动障碍的预测指标。

原始出处:

Sorensen LG, et al. Abstract 30. Presented at: The Liver Meeting; Nov. 11-15, 2016; Boston.

Children live with low HRQOL, motor skill deficits post-acute liver failure
.Healio.November 13, 2016

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1635775, encodeId=eddc1635e75d8, content=<a href='/topic/show?id=9e5781499dd' target=_blank style='color:#2F92EE;'>#肝衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81499, encryptionId=9e5781499dd, topicName=肝衰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fedc22527786, createdName=1249884fm94暂无昵称, createdTime=Sun Aug 20 02:51:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158440, encodeId=8378158440c8, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Nov 27 08:46:31 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156852, encodeId=51b715685242, content=值得学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLMzGpMQ8w4I7FpiblCXNcmI6O7TDINutbaicEUpoYFR1rWqn3kTbulfMhT0iaPFurLz2ddEcWe3BiciaQ/0, createdBy=5f6e1724878, createdName=136****0753赵, createdTime=Sat Nov 19 11:53:37 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156851, encodeId=770c156851a4, content=值得学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLMzGpMQ8w4I7FpiblCXNcmI6O7TDINutbaicEUpoYFR1rWqn3kTbulfMhT0iaPFurLz2ddEcWe3BiciaQ/0, createdBy=5f6e1724878, createdName=136****0753赵, createdTime=Sat Nov 19 11:53:30 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290460, encodeId=e2de129046097, content=<a href='/topic/show?id=fb34523817d' target=_blank style='color:#2F92EE;'>#急性肝衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52381, encryptionId=fb34523817d, topicName=急性肝衰竭)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f54230, createdName=xlysu, createdTime=Wed Nov 16 01:51:00 CST 2016, time=2016-11-16, status=1, ipAttribution=)]
    2016-11-27 李东泽

    很好,不错,以后会多学习

    0

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    2016-11-19 136****0753赵

    值得学习。

    0

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    2016-11-19 136****0753赵

    值得学习。

    0

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近期发表在Annals of Internal Medicine的数据显示,急性肝衰竭(ALF)的成年患者,其总生存率和无移植存活率现在提高!南卡罗来纳医药大学胃肠和肝脏病学的Adrian Reuben和同事还提到,数据中ALF的特征和严重度等并没有显著改变。ALF患者恶化十分迅速,在器官移植系统中的紧急度排名第一。ALF患者通常会在ICU里进行呼吸和循环的支持、透析、抗生素等治疗。N-乙酰半胱氨

AM J HUM GENET:破解幼儿急性肝衰竭病因之谜

幼儿急性肝功能衰竭是一种罕见但威胁生命的疾病。它进程通常极为迅速,例如在患儿发烧时。然而有一半左右的患儿的病因仍然还未知。最近由慕尼黑工业大学(TUM),亥姆霍兹慕尼黑和海德堡大学医院领导的一个国际合作研究项目中,研究人员利用全基因组测序技术揭示了一个特定的基因突变,影响了细胞的运输过程,从而导致该疾病的发生发展。 根据欧盟的资料,如急性肝功能衰竭这类的疾病是被归类为罕见疾病(10,000人中影

DDW 2016:对乙酰氨基酚所致的急性肝损伤和急性肝衰竭更多见于女性

消化疾病周2016(DDW)称,虽然对乙酰氨基酚引起的急性肝损伤和急性肝衰竭比例在女性中比例高于男性,但是女性的生存结果并不会更差。加州大学的Jessica Rubin博士和同事对2000-2015年间加入美国急性肝衰竭研究小组的患者数据进行了分析,共涉及1066名患者,其中有202名患者是急性肝损伤,864名患者为急性肝衰竭。而接下来要谈的结果是针对这864名急性肝衰竭患者的数据分析,其中有65