Hypertension:磁共振成像评估的主动脉弓脉搏波速度作为心血管事件的预测指标!

2017-07-04 xing.T MedSci原创

由此可见,磁共振成像评估的主动脉弓PWV是中年(45-54岁)个体心血管事件的重要预测因子,而在一个多种族人群中主动脉弓PWV与老年心血管疾病并不存在相关性。

通过磁共振成像评估的主动脉弓脉搏波传导速度(PWV)对心血管疾病(CVD)事件的预测价值尚未完全建立。近日,心血管权威杂志Hypertension上发表了一篇研究文章,该研究的目的是通过MESA研究(动脉粥样硬化的多民族研究)评估主动脉弓PWV与心血管病事件发生之间的相关性。

研究人员使用磁共振成像测量了来自于MESA研究的3527名无明显心血管疾病的参与者基线的主动脉弓PWV(基础平均年龄为62±10岁,47%为男性)。研究人员采用Cox回归评估了发生心血管事件(冠心病、脑卒中、短暂性脑缺血发作或心脏衰竭)的风险与主动脉弓PWV的相关性,在调整了年龄、性别、种族和心血管疾病的危险因素。

研究人员发现主动脉弓PWV的平均值为7.4m/s(四分位间距范围为5.6-10.2)。主动脉弓PWV与年龄之间对于结局存在显著的交互作用,所以分析是由年龄段进行分层(45-54岁和>54岁)。在10年随访中发生了456次心血管事件。45到54岁的参与者的主动脉弓PWV与独立于心血管病危险因素的心血管事件有着显著的相关性(PWV每增加1个对数变换,风险比为1.44;95%可信区间为1.07-1.95;P=0.018),而对于>54岁的患者则没有(P=0.93)。

由此可见,磁共振成像评估的主动脉弓PWV是中年(45-54岁)个体心血管事件的重要预测因子,而在一个多种族人群中主动脉弓PWV与老年心血管疾病并不存在相关性。

原始出处:

Yoshiaki Ohyama,et al. Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events The MESA (Multi-Ethnic Study of Atherosclerosis).Hypertension.2017. https://doi.org/10.1161/HYPERTENSIONAHA.116.08749

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createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 19 01:35:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643478, encodeId=8e8616434e8d8, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Oct 26 04:35:00 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222042, encodeId=8681222042e3, content=好文章学习并分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jul 14 06:45:34 CST 2017, time=2017-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219019, encodeId=6b4f219019ea, content=感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Jul 06 06:41:39 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218983, encodeId=33a4218983f8, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Jul 06 05:45:43 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341568, encodeId=fc331341568ea, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407000, encodeId=2c66140e00044, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415160, encodeId=3e1a141516096, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490479, encodeId=b82f14904e9a7, content=<a href='/topic/show?id=02852316569' target=_blank style='color:#2F92EE;'>#主动脉弓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23165, encryptionId=02852316569, topicName=主动脉弓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef708763411, createdName=chenhongpeng, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-14 大爰

    好文章学习并分享!

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Jul 06 05:45:43 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341568, encodeId=fc331341568ea, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407000, encodeId=2c66140e00044, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415160, encodeId=3e1a141516096, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490479, encodeId=b82f14904e9a7, content=<a href='/topic/show?id=02852316569' target=_blank style='color:#2F92EE;'>#主动脉弓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23165, encryptionId=02852316569, topicName=主动脉弓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef708763411, createdName=chenhongpeng, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-06 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

  6. 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href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415160, encodeId=3e1a141516096, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490479, encodeId=b82f14904e9a7, content=<a href='/topic/show?id=02852316569' target=_blank style='color:#2F92EE;'>#主动脉弓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23165, encryptionId=02852316569, topicName=主动脉弓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef708763411, createdName=chenhongpeng, createdTime=Thu Jul 06 01:35:00 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-06 大爰

    学习了谢谢分享!!

    0

  7. 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这些结果进一步支持动脉硬化是血液透析患者显著的心血管危险因素。

Hypertension:高baPWV和血压控制不良的患者,发生卒中风险**

脉搏波传导速度(PWV)可影响抗高血压药物对心血管疾病的预防作用。PWV或PWV和血压控制是否是卒中的独立预测因子研究较少。纵向分析检测臂踝PWV(baPWV),血压控制及baPWV和血压控制对首发卒中风险的作用。本报告包括中国脑卒中一级预防试验的亚组中(CSPPT)3310例高血压成年人,检测基线baPWV。随访时间的中位数为4.5年,111受试者发生卒中。与baPWV最低四分位数的受试者相比,