J Periodontol: 口服益生素与体外环境对牙周健康的影响

2018-07-22 MedSci MedSci原创

近来，口腔健康引入了益生元的概念。在双菌种竞争测定中已经鉴定出很少的潜在口服益生元，显示出对有益细菌的刺激作用并且通过这抑制致病菌种的生长。该研究旨在通过将生物膜组合物转向更有益的菌种主导的微生物群来验证先前鉴定的潜在益生元底物对多种类培养物的影响。

近来，口腔健康引入了益生元的概念。在双菌种竞争测定中已经鉴定出很少的潜在口服益生元，显示出对有益细菌的刺激作用并且通过这抑制致病菌种的生长。该研究旨在通过将生物膜组合物转向更有益的菌种主导的微生物群来验证先前鉴定的潜在益生元底物对多种类培养物的影响。

将含有14种模型口腔细菌的恒化培养物用于生长生物膜24小时，随后用益生元溶液一天三次处理，连续3天。此外，研究了环境因素如pH，营养物可用性，氧浓度和益生元剂量对益生元物质功效的影响。

结果：三种潜在的益生元底物N-乙酰基-D-甘露糖胺，琥珀酸和Met-Pro能够使有益比例> 95％。虽然益生元溶液的pH值对益生元效应没有影响，但养分可用性，氧浓度和益生元处理的相互作用会导致微生物组成的显着变化，证实N-乙酰-D-甘露糖胺是最有希望的口服益生元基质。实验显示出了明显的剂量依赖性效应，N-乙酰基-D-甘露糖胺的浓度为1.0和1.5M时导致97％有益菌的生物膜组成。

在口腔健康中引入益生元概念可能是治疗和预防口腔疾病和促进口腔健康的有效方法。

原始出处：

Vera Slomka， et al. Oral prebiotics and the influence of environmental conditions in vitro. Journal of Periodontology. 2018 June. doi： 10.1002/JPER.17-0437

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2018-08-22 12498c32m80暂无昵称

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2019-01-23 feather89

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2018-07-25 衣带渐宽

学习

55 0
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2018-07-23 liuyong2982

#牙周#

24 0
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2018-07-22 清风拂面

谢谢分享学习

53 0
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2018-07-22 龙胆草

学习谢谢分享

55 0
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2018-07-22 zb1235672

学习了！！！！

0 0
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2018-07-22 orangesking

好

53 0
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2018-07-22 yjs木玉

学习学习再学习

23 0

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