Allergy Asthma Immunol Res:屋尘螨敏感的老年人鼻炎患者中,舌下免疫治疗的效果和安全性评估

2018-10-26 AlexYang MedSci原创

最近,有研究人员确定了屋尘螨(HDM)舌下免疫治疗(SLIT)在患有AR的老年人患者中治疗的效果和安全性。研究包括了45名年龄不小于60岁的HDM诱导的AR患者,并分为2个小组,分别为SLIT治疗组(n=30)和对照组(n=15)。研究发现,在人口统计特征,鼻黏膜总症状得分(STSS),皮肤对HDMs的反应或者对HDMs的血清总的/特异的lgE水平在2个小组之间均没有显著额差异。在第1年,2个小组

最近,有研究人员确定了屋尘螨(HDM)舌下免疫治疗(SLIT)在患有AR的老年人患者中治疗的效果和安全性。

研究包括了45名年龄不小于60岁的HDM诱导的AR患者,并分为2个小组,分别为SLIT治疗组(n=30)和对照组(n=15)。研究发现,在人口统计特征,鼻黏膜总症状得分(STSS),皮肤对HDMs的反应或者对HDMs的血清总的/特异的lgE水平在2个小组之间均没有显著额差异。在第1年,2个小组的鼻症状得分和RTSS均显著下降(P<0.05),而在2组之间,鼻症状得分和RTSS第1年的减少比例上也没有显出的差异(P<0.05);但是,鼻内镜症状得分在SLIT组中显著下降(P<0.05)。免疫学研究表明了SLIT治疗组中,血清特异性lgA水平和CD203c在嗜碱性粒细胞中的表达在V5时显著减少(分别为P = 0.011和P = 0.001),而在对照组中没有上述显著性。与治疗组相比,对照组需要更多的药物治疗,但是在副作用方面没有差异。

最后,研究人员指出,HDM-SLIT第1年的治疗能够改善症状,并且还可以在老年鼻炎患者中诱导免疫调节。

原始出处:

Kim JH, Lee JH, Ye YM et al. Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites. Allergy Asthma Immunol Res. Nov 2018.

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    2018-12-19 skhzy
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    2018-10-28 膀胱癌
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    2018-10-27 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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过敏性鼻炎(AR)越来越成为一种患者自身治疗的疾病。不多于70%的患者自己选择购买药物进行治疗,且没有专业人员的干预,其治疗结果总是令人不满意,这也导致了鼻炎不良治疗,增加了AR治疗对个人和社会的负担。然而,没有外部的影响也就没有上述情况的发生。最近,有研究人员确定了促使患者做出AR治疗决定的关键因素。为了达到上述目的,研究人员利用一个社交网络理论构架来描绘出患者的AR网络,并且在该网络中鉴定影响