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CLIN CANCER RES：SMAD4缺失与头颈部肿瘤细胞西妥昔单抗耐药和MAPK/JNK活化有关

2017-09-12 MedSci MedSci原创

头颈部肿瘤SMAD4耐药
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已有研究证实了SMAD4表达下调与头颈部鳞状细胞癌（HNSCC）西妥昔单抗耐药有关。CLIN CANCER RES近期发表了一篇文章，进一步阐明头颈部鳞状细胞癌SMAD4缺失的临床意义。

已有研究证实了SMAD4表达下调与头颈部鳞状细胞癌（HNSCC）西妥昔单抗耐药有关。CLIN CANCER RES近期发表了一篇文章，进一步阐明头颈部鳞状细胞癌SMAD4缺失的临床意义。

作者通过免疫组化分析了130例新发头颈部鳞状细胞癌标本和43例复发头颈部鳞状细胞癌标本，并与临床病理数据进行相关统计分析。在体内和体外实验中通过对HPV阴性头颈部鳞状细胞癌细胞系进行shRNA敲除和基因重建研究SMAD4发挥的作用。研究结果表明，SMAD4缺失与一种侵袭性强，HPV阴性，西妥昔单抗耐药亚型有感。作者在TCGA-HNSCC数据库和GEO中的独立口腔鳞状细胞癌队列中发现SMAD4低表达标本肿瘤细胞存活和抗凋亡通路通常出现调节异常。头颈部鳞状细胞癌细胞系SMAD4敲除会诱导西妥昔单抗耐药并在体内实验鼠模型中降低生存情况。研究还发现JNK和MAPK活化是西妥昔单抗耐药的调节因子，为EGFR和JNK/MAPK同时抑制改善SMAD缺失的头颈部鳞状细胞癌克服西妥昔单抗耐药治疗提供了理论基础。

文章最后认为，SMAD4表达缺失是西妥昔单抗耐药的特征，在HPV阴性头颈部鳞状细胞癌中SMAD4表达可以作为EGFR/MAPK或EGFR/JNK抑制敏感或耐药的决定因素。

原始出处：
Hiroyuki Ozawa,Ruchira S.Ranaweera,et al.SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells.CLIN CANCER RES.September 2017 doi:10.1158/1078-0432.CCR-16-1686

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    2018-05-01 wshxjq

    #Smad#

    0

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    2018-05-17 chengjn

    #西妥昔#

    0

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    2018-02-28 lidong51

    #MAPK#

    0

  4. 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14 00:03:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589730, encodeId=7a001589e30f5, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Thu Sep 14 00:03:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243509, encodeId=9d602435094c, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 13 08:13:50 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243386, encodeId=9a6d24338661, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed Sep 13 00:14:02 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-14 ylzr123

    好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 13 08:13:50 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243386, encodeId=9a6d24338661, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed Sep 13 00:14:02 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-14 hmwwww

    #肿瘤细胞#

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 13 08:13:50 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243386, encodeId=9a6d24338661, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed Sep 13 00:14:02 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-14 江川靖瑶

    #SMA#

    0

  7. 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14 00:03:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589730, encodeId=7a001589e30f5, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Thu Sep 14 00:03:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243509, encodeId=9d602435094c, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 13 08:13:50 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243386, encodeId=9a6d24338661, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed Sep 13 00:14:02 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-14 wshxjq

    #头颈部#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1794130, encodeId=dc2b1e941302e, content=<a href='/topic/show?id=09e61642864' target=_blank style='color:#2F92EE;'>#Smad#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16428, encryptionId=09e61642864, topicName=Smad)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Tue May 01 05:03:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679436, encodeId=af2c16e94368b, content=<a href='/topic/show?id=d2ea9048398' target=_blank style='color:#2F92EE;'>#西妥昔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90483, encryptionId=d2ea9048398, topicName=西妥昔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=271a27776763, 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14 00:03:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589730, encodeId=7a001589e30f5, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Thu Sep 14 00:03:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243509, encodeId=9d602435094c, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 13 08:13:50 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243386, encodeId=9a6d24338661, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed Sep 13 00:14:02 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-14 木头人519

    #颈部#

    0

  9. 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14 00:03:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589730, encodeId=7a001589e30f5, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Thu Sep 14 00:03:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243509, encodeId=9d602435094c, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 13 08:13:50 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243386, encodeId=9a6d24338661, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed Sep 13 00:14:02 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-13 ylzr123

    好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

    0

  10. 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    2017-09-13 luominglian113

    学习了.谢谢分享

    0

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