AJG：他汀类药物或可降低炎症性肠道疾病风险

2016-08-03 佚名中华医学信息导报

美国一项研究显示，他汀类药物的使用与炎症性肠病（IBD）的风险较低相关，尤其在老年克罗恩病（CD）患者。研究团队使用了美国一项大型索赔数据库的资料来检查他汀类药物对新发IBD风险的影响。这项分析包括了9000余例患CD或溃疡性结肠炎（UC）的成年人，以及46000例相匹配的对照人群。接触任何他汀类药物都与IBD（OR 0.68）、CD（OR 0.64）和UC（OR 0.70）风险的明显降低相关。按

美国一项研究显示，他汀类药物的使用与炎症性肠病（IBD）的风险较低相关，尤其在老年克罗恩病（CD）患者。

研究团队使用了美国一项大型索赔数据库的资料来检查他汀类药物对新发IBD风险的影响。这项分析包括了9000余例患CD或溃疡性结肠炎（UC）的成年人，以及46000例相匹配的对照人群。

接触任何他汀类药物都与IBD（OR 0.68）、CD（OR 0.64）和UC（OR 0.70）风险的明显降低相关。按他汀类药物类型和治疗强度分层的效果都相似。在老年患者中，抗CD的保护作用最强。

尽管缺乏剂量-反应关系的资料，但低剂量他汀类药物可能减少炎症反应。使用他汀类药物可能是调节IBD风险的一个新的因素。

研究人员建议，是否考虑将他汀类药物添加到治疗轻度IBD的药物，并作进一步研究。如果本研究结果得到其他研究的证实，他汀类药物也可以作为预防性措施来处理发展为高风险IBD的高危患者，然而这种可能性还需要进一步研究确定。

原始出处：Ryan Ungaro, Helena L Chang, Justin Cote-Daigneaut, Saurabh Mehandru, Ashish Atreja and Jean-Frederic Colombel.Statins Associated With Decreased Risk of New Onset Inflammatory Bowel Disease.The American Journal of Gastroenterology.14 June 2016.

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2017-06-25 ms6390871039024434

#他汀类药#

29 0
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2017-06-07 minzju5052

#AJG#

26 0
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2016-08-05 花花1368

#疾病风险#

34 0
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2016-08-05 guozhenyu

#肠道疾病#

40 0
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2016-08-05 12498dd9m15暂无昵称

#炎症性#

33 0
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2016-08-04 小M医师

看着挺厉害的

63 0
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2016-08-04 月半月半

好厉害！

65 0
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2016-08-04 月半月半

很有意思

71 0
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2016-08-04 深海的鱼

又一项新研究

69 0

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