Eur Heart J:非心脏手术围手术期急性心肌梗死!

2017-07-03 xing.T MedSci原创

由此可见,在接受非心脏手术的病人中围手术期AMI发生率为0.9%,并且与住院死亡率密切相关。这种患者的介入治疗可以减轻这种过度的风险,并且进一步研究围手术期AMI的治疗是很有必要的。

急性心肌梗死(AMI)是非心脏手术后的重要心血管并发症。近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员试图评估围手术期AMI的国内趋势、治疗和预后。

研究人员使用美国国家住院病人样本确定了在2005年至2013年期间接受非心脏手术的患者。围手术期AMI随时间评估。研究人员采用倾向评分匹配法将AMI患者分组,分别接受介入治疗(定义为心导管检查或冠状动脉血运重建术)或保守治疗。该研究的主要结局为院内全因死亡率。

在9566277非心脏手术的住院患者中,发生围手术期AMI的有84093例(0.88%)患者。随着时间的推移,围手术期AMI发生率为每100000例下降了170例[95%可信区间(95%CI)为158-181],从2005年的898例降低至2013年的729例(趋势P<0.0001)。围手术期AMI最常见于血管(2%)、移植(1.6%)和胸部(1.5%)手术患者。围手术期AMI患者的住院死亡率较高,相比于那些没有发生AMI的患者[18% vs. 1.5%,P<0.0001;调整后的比值比(OR)为5.76,95%CI为5.65-5.88]。围手术期AMI的死亡率随时间而下降(调整后OR为0.86,95%CI为0.84-0.88)。在围手术期AMI的34650例患者的倾向性匹配队列,相比于保守治疗,介入治疗死亡率降低(8.9% vs. 18.1%,P<0.001  ;OR为0.44,95%CI为0.41-0.47)。

由此可见,在接受非心脏手术的病人中围手术期AMI发生率为0.9%,并且与住院死亡率密切相关。这种患者的介入治疗可以减轻这种过度的风险,并且进一步研究围手术期AMI的治疗是很有必要的。

原始出处:


Nathaniel R. Smilowitz,et al. Perioperative acute myocardial infarction associated with non-cardiac surgery. Eur Heart J. https://doi.org/10.1093/eurheartj/ehx313

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    2017-07-05 zhaojie88
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    2017-07-05 slcumt
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    2017-07-03 Julie W

    急性心肌梗死(AMI)是非心脏手术后的重要心血管并发症。近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员试图评估围手术期AMI的国内趋势、治疗和预后。

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