Circulation:近两成非心脏手术患者会发生围术期心肌损伤

2017-12-13 许菁 中国循环杂志

Circulation杂志发表研究表明,16%的非心脏手术患者发生围手术期心肌损伤。


Circulation杂志发表研究表明,16%的非心脏手术患者发生围手术期心肌损伤。
 
本研究中,定义围术期心肌损伤为高敏肌钙蛋白T(hs-cTnT)较术前绝对增长>14 ng/L。
 
发生围手术期心肌损伤患者中,只有6%有胸痛。82%的患者没有表现出任何症状。
 
围手术期心肌损伤患者的30天死亡率是无围手术期心肌损伤者的6倍(9.8% vs 1.6%),1年死亡率升高(22.5% vs 9.3%)。
 
多变量回归分析显示,围手术期心肌损伤的患者30天死亡风险增加近3倍,1年死亡风险增加近2倍。
 
研究连续纳入患者2018例,接受2546次手术。患者的中位年龄为74岁,女性为42%岁。
 
相关专家表示,接受非心脏手术的患者是否应该接受hs-cTnT筛选仍不能定论。
 
在大多数情况下,心肌细胞损伤可能是由供需不匹配引起的低血压、贫血、心动过速引起的。
 
据悉,只有三家医院(2家在瑞士和1家在巴西)在非心脏手术患者做常规肌钙蛋白检测。
 
对于非心脏手术患者的hs-cTnT筛查,研究者提醒,术前hs-cTnT检测需要区分围手术期心肌损伤与慢性hs-cTnT升高。在该研究中,51%的患者术前hs-cTnT水平已经达到或超过14 ng/L。
 
原始出处:

Puelacher C,Lurati Buse G,Seeberger D,et al. Perioperative Myocardial Injury After Noncardiac Surgery: Incidence,Mortality, and Characterization. Circulation. 2017 Dec 4. pii:CIRCULATIONAHA.117.030114. doi: 10.1161/CIRCULATIONAHA.117.030114. [Epub aheadof print].

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