J Hypertens:血管内皮功能障碍与蛋白尿!

2018-01-27 xing.T MedSci原创

由此可见,这是第一个以人群为基础的研究,它提供了直接证据表明微血管内皮功能障碍与蛋白尿有关,并且这种相关性在2型糖尿病患者中更为明显。

蛋白尿被认为是微血管和大血管内皮功能障碍的生物标志物。然而,微血管内皮功能障碍与蛋白尿有关的直接证据十分有限。此外,实验数据显示微血管内皮功能障碍与蛋白尿之间的相关性在糖尿病患者中要强于无糖尿病患者。

近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,在糖尿病较多的以一般人群为基础的马斯特里赫特研究中,研究人员评估了闪烁光诱导视网膜小动脉扩张(n=2095)和热诱导皮肤充血(n=1508)与24 h尿蛋白之间的横断面相关性。研究人员采用线性回归分析来调整年龄、性别、2型糖尿病和心血管疾病危险因素。此外,还评估了与2型糖尿病的统计学相互作用。

受试者蛋白尿的中位数[间距范围]为6.5[3.9-11.6]mg/24h,并且8.2%的个体蛋白尿不低于30mg/24h,在调整后,在闪烁光诱导视网膜小动脉扩张最小的四分位数与最大扩张的患者相比蛋白尿要高出1.168倍(95%可信区间为1.046-1.303),这种相关性在2型糖尿病的参与者中明显更强(相互作用P<0.10)。此外,热诱导皮肤充血每降低100个百分点,2型糖尿病患者蛋白尿的增加1.022倍(1.010-1.035),而在非糖尿病患者中与蛋白尿无关(相互作用P<0.10)。

由此可见,这是第一个以人群为基础的研究,它提供了直接证据表明微血管内皮功能障碍与蛋白尿有关,并且这种相关性在2型糖尿病患者中更为明显。

原始出处:

Martens, Remy,et al. Microvascular endothelial dysfunction is associated with albuminuria: the Maastricht Study.Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Microvascular_endothelial_dysfunction_is.97529.aspx

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    2018-08-02 feather89
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    2018-08-30 医路繁花相送

    学习中

    0

  4. 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    2018-01-27 1ddf0692m34(暂无匿称)

    学习了.涨知识

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