JCEM:胰岛素抵抗和β细胞功能障碍与心脏代谢风险模式的关系

2018-03-27 MedSci MedSci原创

众所周知胰岛素抵抗和β细胞功能障碍是协同诱导糖尿病和相关心脏代谢性疾病的两个主要因素,而近日在JCEM上发表的一篇文章则研究了胰岛素抵抗和β细胞功能障碍与多种心脏代谢疾病(包括肥胖,中心性肥胖,糖尿病,血脂异常和高血压)的发病的独立及联合关联。

众所周知胰岛素抵抗和β细胞功能障碍是协同诱导糖尿病和相关心脏代谢性疾病的两个主要因素,而近日在JCEM上发表的一篇文章则研究了胰岛素抵抗和β细胞功能障碍与多种心脏代谢疾病(包括肥胖,中心性肥胖,糖尿病,血脂异常和高血压)的发病的独立及联合关联。

研究人员进行了一项纳入全国有代表性的中国成人93,690人的研究,主要的测量结果是通过稳态模型评估胰岛素抵抗(HOMA-IR)和β细胞功能HOMA(HOMA-B)评估胰岛素抵抗和β细胞功能障碍。

研究结果显示高HOMA-IR与所有预估的心脏代谢疾病的高发病率独立相关;而低HOMA-B与糖尿病、血脂异常和高血压的高发病率独立相关,但是与肥胖和中心性肥胖的低发病率相关。当联合观察时,HOMA-IR和HOMA-B与多种心脏代谢疾病的关联显示出不同的模式并伴有不同的强度:观察到的最强的关联是糖尿病,低HOMA-B与糖尿病高发生率相关而与HOMA-IR无关;与血脂异常和高血压患病率的联合关系似乎是相加的,并具有适度的变化趋势;低HOMA-B与肥胖或中心性肥胖的高发病率无关,除非与高HOMA-IR结合观察。

上述研究表明胰岛素抵抗较β细胞功能障碍更与普遍的心脏代谢疾病相关。胰岛素抵抗和β细胞功能障碍的组合表明其与中国成人的心脏代谢风险模式有不同的关系。

原始出处:

Tiange Wang.et al. Insulin resistance and beta-cell dysfunction in relation to cardiometabolic risk patterns. J Clin Endocrinol Metab. 2018.

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  5. 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  6. 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  7. 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  9. 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topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Thu Mar 29 10:34:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300246, encodeId=5ac3300246c1, content=学习了.好文章., beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Mar 27 19:57:01 CST 2018, time=2018-03-27, status=1, ipAttribution=)]
    2018-03-27 1e0f8808m18(暂无匿称)

    学习了.好文章.

    0

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肥胖诱导的代谢疾病涉及几个器官之间通过循环因子的功能整合,但至今为止,我们对肝脏和内脏脂肪组织(VAT)之间的关联还知之甚少。

Lancet Diabetes Endo:2型糖尿病的新亚组分类方法及其与预后的关系

研究认为,研究考察了2型糖尿病患者导致疾病进展以及并发症的5个相关因素,根据新因素进行准确的亚组分析是2型糖尿病精密医疗的第一步

Neurology:中年胰岛素抵抗增加老年阿尔兹海默风险

研究认为,对于无痴呆症状的中年人群,胰岛素抵抗导致老年期间的阿尔兹海默风险增加

Diabetes Obes Metab:补充白藜芦醇对超重和胰岛素抵抗患者肝脏脂肪含量的影响!

总之,这些数据表明白藜芦醇补充剂是安全的,但它不会显著影响人类肝脏脂肪含量和心脏代谢风险参数。