PLOS Biol:科学家提出克服抗生素耐药性治疗的新方法!

2017-12-30 枫丹白露 来宝网

抗生素的抗药性对严重的细菌感染的治疗提出了严重且有时是致命的挑战。在12月28日发表在“开放获取期刊PLOS生物学”杂志上的一篇新论文中,佐治亚理工学院的Kristofer Wollein Waldetoft和Sam P. Brown提出,开发适用于轻度感染的替代疗法有助于减缓抗生素耐药性的发展和蔓延。

轻度感染的替代治疗可以帮助抵抗抗生素耐药抗生素的抗药性对严重的细菌感染的治疗提出了严重且有时是致命的挑战。在12月28日发表在“开放获取期刊PLOS生物学”杂志上的一篇新论文中,佐治亚理工学院的Kristofer Wollein Waldetoft和Sam P. Brown提出,开发适用于轻度感染的替代疗法有助于减缓抗生素耐药性的发展和蔓延。

当细菌病原体发生改变时,会出现抗生素耐药性,从而降低药物的有效性,并在这些耐药菌株繁殖时成为严重的问题。仅在美国,每年就有超过20,000人死于抗生素耐药性感染。大多数研究,以确定替代抗生素,如杀菌病毒,专注于针对严重感染使用替代疗法。但是,这样的努力取得了有限的成功。

为了确定可能更有效的方法,Waldetoft和Brown回顾了以前关于抗生素使用的研究。他们用一个进化框架来分析这些研究的数据,并确定抗生素广泛应用于某些轻度感染可能对抗生素耐药性的发展作出重大贡献。这部分是因为抗生素可以选择患者中存在的任何细菌的抗性,而不仅仅是目标缺陷。由于许多抗生素以相似的方式运作,单一抗生素可以促进对许多药物的抗性。因此,他们认为开发替代疗法的研究工作应该将重点从严重感染转移到温和感染。

分析表明,对于某些轻微感染(可能更容易发展)的替代疗法可能间接减缓更危险的病菌对抗生素耐药性的发展。这可能有助于保持抗生素对抗新药难以发展的严重感染的能力。

作者指出,开发非抗生素替代治疗轻度感染仅仅是抗击抗生素耐药性的一种策略。其他策略包括抗生素治疗的短期疗程和使用针对较窄范围物种的抗生素。

原始出处:

Kristofer Wollein Waldetoft et al, Alternative therapeutics for self-limiting infections—An indirect approach to the antibiotic resistance challenge, PLOS Biology (2017). DOI: 10.1371/journal.pbio.2003533.

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    2018-08-24 sunylz
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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jan 09 07:16:10 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275541, encodeId=641d2e5541cc, content=用另一种感染替代目前感染?, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq3V1R96z2QQE9Z3NbuTttaIokTYyd09Ln47P6OKEhWtAb0g9omd7CudWfwOlsxwRuDKbDSxFSJ0A/132, createdBy=3f492235990, createdName=白水鉴心, createdTime=Fri Jan 05 01:40:59 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274662, encodeId=74132e466295, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Jan 02 08:01:50 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274642, encodeId=eb002e46426b, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Tue Jan 02 07:19:22 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274630, encodeId=84c02e463098, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Jan 02 06:41:22 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441646, encodeId=a4ed144164689, content=<a href='/topic/show?id=64655544106' target=_blank style='color:#2F92EE;'>#抗生素耐药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55441, encryptionId=64655544106, topicName=抗生素耐药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1cac4876897, createdName=12498bf3m26暂无昵称, createdTime=Mon Jan 01 10:00:00 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604455, encodeId=96cd16044552d, content=<a href='/topic/show?id=13235544294' target=_blank style='color:#2F92EE;'>#抗生素耐药性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55442, encryptionId=13235544294, topicName=抗生素耐药性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69fc19187130, createdName=liuyg0234, createdTime=Mon Jan 01 10:00:00 CST 2018, time=2018-01-01, status=1, ipAttribution=)]
    2018-01-09 wzb521zf

    一起学习学习

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Jan 02 06:41:22 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441646, encodeId=a4ed144164689, content=<a href='/topic/show?id=64655544106' target=_blank style='color:#2F92EE;'>#抗生素耐药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55441, encryptionId=64655544106, topicName=抗生素耐药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1cac4876897, createdName=12498bf3m26暂无昵称, createdTime=Mon Jan 01 10:00:00 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604455, encodeId=96cd16044552d, content=<a href='/topic/show?id=13235544294' target=_blank style='color:#2F92EE;'>#抗生素耐药性#</a>, beContent=null, objectType=article, 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    2018-01-05 白水鉴心

    用另一种感染替代目前感染?

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Jan 02 06:41:22 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441646, encodeId=a4ed144164689, content=<a href='/topic/show?id=64655544106' target=_blank style='color:#2F92EE;'>#抗生素耐药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55441, encryptionId=64655544106, topicName=抗生素耐药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1cac4876897, createdName=12498bf3m26暂无昵称, createdTime=Mon Jan 01 10:00:00 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604455, encodeId=96cd16044552d, content=<a href='/topic/show?id=13235544294' target=_blank style='color:#2F92EE;'>#抗生素耐药性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55442, encryptionId=13235544294, topicName=抗生素耐药性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69fc19187130, createdName=liuyg0234, createdTime=Mon Jan 01 10:00:00 CST 2018, time=2018-01-01, status=1, ipAttribution=)]
    2018-01-02 三生有幸9135

    学习一下谢谢分享

    0

  7. 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    2018-01-02 stupidox

    学习了.谢谢分享

    0

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    2018-01-02 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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在1992年,我们还以为全球变暖只是一个假说,但是在2002年的地图上,我们已经可以清晰地看到冰川消融。那些科学家具有前瞻性的研究,或许离我们太过遥远,或许像危言耸听一样令人不愿接受,但大自然不会停下脚步,当我们被困于短暂的眼前利益时,未来或许会倏然到来,猝不及防。美国医学院院士马丁·布莱泽(Martin J. Blaser),几十年来一直致力于微生物菌群及耐药细菌研究。他认为滥用抗生素及剖宫

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研究认为,利福平辅助治疗对于金黄色葡萄球菌感染患者效果不显著