Stroke:蛛网膜下腔扩张预示脑出血血肿扩大

2020-03-23 MedSci原创 MedSci原创

SAHE可预测脑叶ICH的HE,这可能在针对HE的临床实践或未来试验中改善HE的风险分层。研究人员需要进一步的研究来证实这些结果并确定其潜在的生物学机制。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,该研究旨在评估脑出血(ICH)患者蛛网膜下腔扩张(SAHE)是否与血肿扩大(HE)有关。

研究人员对意大利3所教学医院收治的原发性自发性ICH患者进行回顾性分析。研究人群分为开发队列和重复队列。由对临床数据不知情的调查人员根据基线无对比增强的计算机断层扫描评分对SAHE进行分级。该研究感兴趣的主要结局是HE,定义为ICH增长>33%和/或>6mL。研究人员使用根据ICH位置(脑叶和非脑叶)分层的多变量Logistic回归探索HE的预测因子。

该研究分别有360例和192例患者被纳入开发队列和重复队列。SAHE被认为具有良好的评价者间可靠性(K=0.82),其发生频率在开发队列中为27.8%,在重复队列中为24.5%。在单因素分析中,HE在SAHE患者中更为常见(52.0% vs. 27.3%;P<0.001)。在控制logistic回归中的混杂因素时,SAHE是脑叶HE的独立预测因子(比值比为6.00[95%CI为2.16-16.64];P=0.001),而在非脑叶性脑出血中与HE无关(比值比为0.55[95%CI为0.17-1.84];P=0.334)。重复队列证实脑ICH合并SAHE的患者HE风险增加(比值比为3.46[95%CI为1.07-11.20];P=0.038)。

由此可见,SAHE可预测脑叶ICH的HE,这可能在针对HE的临床实践或未来试验中改善HE的风险分层。研究人员需要进一步的研究来证实这些结果并确定其潜在的生物学机制。

原始出处:

Andrea Morotti.et al.Subarachnoid Extension Predicts Lobar Intracerebral Hemorrhage Expansion.stroke.2020.https://doi.org/10.1161/STROKEAHA.119.028338

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