Hypertension:夜间收缩血压下降可预测患者预后

2016-04-04 徐媛 MedSci原创

夜间血压下降在临床上尚未得到重视,患者收缩压昼夜比例风险目前尚不清楚。 研究人员进行了高血压患者动态血压监测联合研究”(ABC-H)的临床试验,此项试验中共收纳来自3个地区高血压患者,共收纳17312名患者进行了meta分析。 研究人员对患者收缩压昼夜的比例分先进行了分析,并分别统计了调整24小时收缩压前后的多因素校正风险比率,包括总心血管事件、冠脉事件、卒中、心因性死亡率及总死亡率。患者的收

夜间血压下降在临床上尚未得到重视,患者收缩压昼夜比例风险目前尚不清楚。

研究人员进行了高血压患者动态血压监测联合研究”(ABC-H)的临床试验,此项试验中共收纳来自3个地区高血压患者,共收纳17312名患者进行了meta分析。

研究人员对患者收缩压昼夜的比例分先进行了分析,并分别统计了调整24小时收缩压前后的多因素校正风险比率,包括总心血管事件、冠脉事件、卒中、心因性死亡率及总死亡率。患者的收缩压在24小时内变化在131mmHg-140mmHg,收缩压昼夜比例在0.88-0.93。总共有1769名发生心血管事件、916名患者发生冠脉事件、698名患者发生卒中、450名患者死心血管事件及903名患者死亡。调整24小时收缩压后,患者收缩压昼夜比例可预测预后事件:在一个标准差增幅内,总风险比在1.12-1.23。反常型杓形曲线亦可以预测所有预后事件:总风险比在1.57-1.89。相比于正常杓形曲线,降低型杓形曲线总心血管事件风险升高了27%,而过低型杓形曲线风险主要受降血压治疗影响。异质性在收缩压昼夜比例、降低型杓形曲线、反常型杓形曲线发生心血管事件均较低,而在反常型杓形曲线中发生心血管事件呈中度水平。

基于以上研究表明,在这个最大的荟萃研究分析中,高血压患者夜间收缩血压下降可预测患者预后,且独立于患者24小时收缩压水平影响。

原始出处

Salles GF1, Reboldi G2, Fagard RH2, Cardoso CR2, Pierdomenico SD2, Verdecchia P2, Eguchi K2, Kario K2, Hoshide S2, Polonia J2, de la Sierra A2, Hermida RC2, Dolan E2, O'Brien E2, Roush GC2; ABC-H Investigators.Prognostic Effect of the Nocturnal Blood Pressure Fall in Hypertensive Patients: The Ambulatory Blood Pressure Collaboration in Patients With Hypertension (ABC-H) Meta-Analysis.Hypertension. 2016 Apr

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    2017-02-09 feather89
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    2016-04-05 忠诚向上

    好好学习

    0