Sci Rep:无症状性与症状性重度主动脉瓣狭窄患者的比较

2018-07-09 xiangting MedSci原创

相对于无症状性重度AS患者,症状性患者的主动脉瓣相关事件存在显著过分危险。

无症状性和症状性重度主动脉瓣狭窄(AS)患者的临床预后存在多大差别尚不清楚。

在CURRENT AS注册研究中招募了3,815名连续性重度AS患者,将1808名无症状患者和1215名症状性无心衰(HF)住院患者的长期预后进行了比较(劳力性呼吸困难:N=813,晕厥:N=136,心绞痛:N=266)。

与无症状患者相比,症状性患者的AS严重程度更重、左心室功能更差,而其他基线特征没有太大差异。在中位3.2年的随访期间,62%的症状性患者和38%的无症状患者接受了主动脉瓣置换术(AVR)。症状性患者主要结局指标(主动脉瓣相关死亡或因HF住院的复合)的累积5年发生率高于无症状患者(32.3%vs 27.6%,P<0.001)。调整AVR和其他变量后,症状性患者相对于无症状患者的主要结局指标的风险更大(风险比1.64,95%置信区间1.41-1.96,P<0.001)。

总之,相对于无症状性重度AS患者,症状性患者的主动脉瓣相关事件存在显著过分危险。然而,症状性患者的AVR普及率并不理想。

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