PLoS One:韩国贝赛特氏症病人中癌症风险的分析

2018-01-07 AlexYang MedSci原创

各种免疫调控疾病均与恶性肿瘤非风险的增加相关。然而,贝赛特氏症(BD)与癌症之间的关系仍旧不清楚。最近,有研究人员进行了一个全国性的、基于群体的研究来确定BD病人癌症的风险情况。研究包括了2013年和2014年之间的2402名诊断为BD病人的数据。研究发现,总体癌症的风险(SIR(标准化发生率), 3.54; 95%置信区间, 男性为2.35-5.11 , 女性为1.58-2.92)和实体肿瘤(男

各种免疫调控疾病均与恶性肿瘤非风险的增加相关。然而,贝赛特氏症(BD)与癌症之间的关系仍旧不清楚。最近,有研究人员进行了一个全国性的、基于群体的研究来确定BD病人癌症的风险情况。研究包括了2013年和2014年之间的2402名诊断为BD病人的数据。

研究发现,总体癌症的风险(SIR(标准化发生率), 3.54; 95%置信区间, 男性为2.35-5.11 , 女性为1.58-2.92)和实体肿瘤(男性为1.94-4.69,女性为1.52-2.90)在BD病人中的风险要比普通群体中的风险更大。实体癌症的风险增加具有显著性,包括了男性中的大肠(4.26,8-9.94)、肝脏(4.00; 1.09-10.25)、骨骼和关节软骨(55.66; 1.41-310.14)、前列腺(7.05; 1.45-20.60)和脑/中央神经系统(28.32; 3.43-102.31); 以及女性中的嘴唇/口腔/咽(13.97,1.69-50.47)、肝脏 (12.78; 5.14-26.33)、 肺 (4.35; 1.18-11.13)以及其他女性生殖器官(53.57; 1.36-298.49)和眼睛 (128.26; 3.24-714.59)。另外,BD病人具有比普通人群更高的骨髓增生异常综合征(MDS)风险(男性中为65.72; 7.96-237.41,女性中为53.86; 11.11-157.40),但是在血液癌症中不存在上述情况。最后,研究人员指出,与普通人群相比,韩国BD病人具有总体癌症、一些实体癌症和MDS更高的风险,但不包括血液癌症。

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    2018-01-07 hhh678

    henhao

    0

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    2018-01-07 flysky120

    学习一下知识了

    0

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