Circulation:左心室心内膜消融术后发生脑部栓塞的情况如何?

2017-01-25 xing.T MedSci原创

半数以上接受常规LV消融术的患者(主要为PVC消融)在消融术后出现了新发的脑部栓塞。进一步的研究以了解这些病变的长期后果并确定最佳的预防策略尤为重要。

用导管消融来治疗室性心动过速(VT)、室性早搏(PVC)是很常见的手段。心房颤动进行导管消融与脑部栓塞风险有关,主要是由于低流量左心房心脏电复律和众多消融损伤所致,但心室消融患者脑部栓塞的风险尚未有研究进行过评估。近日,心血管领域权威杂志Circulation上针对这一问题发表了一篇研究文章。

研究人员招募了连续就诊的18例符合研究纳入标准的在9个月内计划进行VT或PVC消融的患者。研究人员比较了进行左心室(LV)消融的患者与那些单纯接受右心室(RV)消融的对照者。研究人员将接受了植入式心脏除颤器或永久起搏器治疗的患者进行排除。射频能量被用于所有患者的消融,而且对于所有进行左室手术的患者运用肝素治疗并达到目标激活凝血时间300-400s。这些参与者在射频消融术前和术后一个星期内均进行了脑磁共振成像(MRI)检查。血栓栓塞性梗死被定义为在液体衰减反转恢复血管分布的脑部MRI中呈现出扩散减少和高信号的新发病灶。

该研究的参与者平均年龄为58岁,半数为男性,半数有高血压病史,多数患者无已知的血管疾病或心力衰竭。进行LV消融术的患者有12例(VT,n=2;PVC,n=10),而只进行RV消融术的患者有6例(VT,n=1;PVC,n=5)。进行LV消融术的7例(58%)患者共经历了16次脑部栓塞事件,而进行RV消融术的患者为0次(P=0.04)。11例患者中的7例(63%)进行逆行射频消融术的患者至少有一处新发脑部损伤。

半数以上接受常规LV消融术的患者(主要为PVC消融)在消融术后出现了新发的脑部栓塞。进一步的研究以了解这些病变的长期后果并确定最佳的预防策略尤为重要。

原始出处:

Isaac R. Whitman,  et al. Brain Emboli After Left Ventricular Endocardial Ablation. Circulation. 2017. 


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    2017-01-28 ylzr123

    进一步研究以了解这些病变的长期后果并确定最佳的预防策略尤为重要。

    0

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    2017-01-26 1dd8aa01m06(暂无匿称)

    好文章学习了

    0