Oxid Med Cell Longev:糖尿病肾病患者细胞衰老的信号

2020-06-16 MedSci原创 MedSci原创

糖尿病肾病是西方国家慢性肾脏病(CKD)的主要原因。值得注意的是,它在中国的发病率迅速上升。心血管疾病和神经系统疾病是常见的并发症,也是患者进展为终末期肾病(ESRD)和死亡的高危风险。然而,糖尿病肾

糖尿病肾病是西方国家慢性肾脏病(CKD)的主要原因。值得注意的是,它在中国的发病率迅速上升。血管疾病和神经系统疾病是常见的并发症,也是患者进展为终末期肾病(ESRD)和死亡的高危风险。然而,糖尿病肾病的发病机制尚未确定。近来受到广泛关注的细胞衰老被认为是糖尿病肾病发生和发展的重要角色。

 

在这个问题上,我们大致回顾了糖尿病肾病中细胞衰老的机制,其中涉及端粒损耗、DNA损伤、表观遗传学改变、线粒体功能障碍、Klotho丢失、Wnt/β-catenin信号激活、持续炎症和尿毒症毒素的积累。

 

此外,我们还强调了糖尿病肾病中细胞衰老的潜在治疗靶点,并为临床策略提供了重要线索。

 

原始出处:

 

Yabing Xiong, Lili Zhou. The Signaling of Cellular Senescence in Diabetic Nephropathy. Oxid Med Cell Longev. 2019 Oct 3;2019:7495629. doi: 10.1155/2019/7495629.  

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    2020-09-11 维他命
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    2020-07-14 jacob9231

    👍🏻

    0

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    2020-06-16 misszhang

    谢谢MedSci提供最新的资讯

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