JACC:去心脏交感神经治疗难治性室性心律失常

2017-06-20 xiangting MedSci原创

CSD可降低难治性VT患者的持续VT和ICD休克复发。

去除心脏交感神经(CSD)已被证明可以减轻结构性心脏病(SHD)和复发性室性心律失常(VT)患者进行植入式心律转复除颤器(ICD)手术的负担。

这项研究评估了CSD的价值和与这一人群结局相关的特征。

国际心脏去交感神经协作组对5个国际中心中因难治性VT或VT风暴患者而进行CSD的患者进行了分析。使用Kaplan-Meier分析来估计没有出现ICD休克、心脏移植和死亡的几率。Cox比例风险模型用于分析CSD后ICD休克复发和死亡率相关的变量。

在2009年至2016年,121例患者(年龄55±13岁,女性26%,平均射血分数30±13%)进行左侧或双侧CSD。一年内没有出现持续VT/ICD休克和ICD休克、移植和死亡的比例分别为58%和50%。CSD将ICD休克负担由研究前一年的平均18±30(中位数10)降低至中位随访时间1.1年时的2.0±4.3(中位数0)(p<0.01)。在多变量分析中,手术前纽约心功能III级和IV级心力衰竭和更长的VT周期长度与复发性ICD休克相关,而较高的纽约心功能分级,较长的VT周期长度和左侧手术可以预测持续性VT/ICD休克复发、死亡和移植的复合终点。 在120例CSD前服用抗心律失常药物的患者中,39例(32%)随访中不再需要服药。

CSD可降低难治性VT患者的持续VT和ICD休克复发。与复发和死亡独立相关的特征包括心脏衰竭、VT周期长度和左侧手术。

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    2017-11-28 hbwxf
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  3. [GetPortalCommentsPageByObjectIdResponse(id=1853657, encodeId=6f35185365ede, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Nov 28 01:41:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325397, encodeId=6e10132539eab, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Jun 22 07:41:00 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528355, encodeId=f41d152835530, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Thu Jun 22 07:41:00 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213166, encodeId=162a213166ab, content=这个研究非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=a7ea2070227, createdName=158****8818, createdTime=Tue Jun 20 17:05:54 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-22 freve
  4. [GetPortalCommentsPageByObjectIdResponse(id=1853657, encodeId=6f35185365ede, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Nov 28 01:41:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325397, encodeId=6e10132539eab, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Jun 22 07:41:00 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1528355, encodeId=f41d152835530, content=<a href='/topic/show?id=74b798601a1' target=_blank style='color:#2F92EE;'>#难治性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98601, encryptionId=74b798601a1, topicName=难治性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ef11916292, createdName=freve, createdTime=Thu Jun 22 07:41:00 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213166, encodeId=162a213166ab, content=这个研究非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=a7ea2070227, createdName=158****8818, createdTime=Tue Jun 20 17:05:54 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-20 158****8818

    这个研究非常好

    0

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