JACC:药物洗脱生物可吸收支架植入远期粥样斑块形成率较高

2018-04-29 MedSci MedSci原创

目前,关于依维莫司洗脱生物可吸收支架(BVS)植入后的新生动脉粥样硬化资料尚缺乏。本研究的目的旨在通过多成像模式包括光学相干断层扫描(OCT)来评估BVS植入五年后新生动脉粥样硬化的状态。本研究纳入了20例ABSORB EXTEND临床试验中的患者,所有患者在基线水平、支架植入1年和5年均进行了OCT检测,并对其支架内和支架外斑块的情况进行了评估。经过平均67个月时间的随访,患者的平均年龄为69

目前,关于依维莫司洗脱生物可吸收支架(BVS)植入后的新生动脉粥样硬化资料尚缺乏。本研究的目的旨在通过多成像模式包括光学相干断层扫描(OCT)来评估BVS植入五年后新生动脉粥样硬化的状态。本研究纳入了20例ABSORB EXTEND临床试验中的患者,所有患者在基线水平、支架植入1年和5年均进行了OCT检测,并对其支架内和支架外斑块的情况进行了评估。经过平均67个月时间的随访,患者的平均年龄为69 ± 8岁。通过对比术后1年和5年的检查结果,研究者发现支架内脂质沉积的新生内膜(17% vs. 61%; p = 0.04)、钙化(28% vs. 94%; p < 0.01)、血管新生(6% vs. 78%; p < 0.01)和薄帽状纤维粥样瘤(0% vs. 22%; p = 0.02)的发生率有明显差异,而支架外斑块的情况在1年和5年时无明显差异。本研究结果显示,药物洗脱生物可吸收支架(BVS 1.1)植入后5年的支架内新生粥样斑块形成比例较高,且对管腔可造成较明显的狭窄。该结果需要在未来更大的样本量中进行验证。原始出处:Noriaki M et al.Neoatherosc

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createdName=liao1619, createdTime=Tue Jan 15 19:05:00 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019787, encodeId=6c792019e8784, content=<a href='/topic/show?id=6c3ce629914' target=_blank style='color:#2F92EE;'>#粥样斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76299, encryptionId=6c3ce629914, topicName=粥样斑块)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Fri Jun 08 07:05:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854019, encodeId=cb211854019ca, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jul 04 16:05:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076869, encodeId=a94a20e686907, content=<a href='/topic/show?id=0b93692e416' target=_blank style='color:#2F92EE;'>#生物可吸收#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69274, encryptionId=0b93692e416, topicName=生物可吸收)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Jun 13 14:05:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325820, encodeId=596c1325820e7, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue May 01 05:05:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330078, encodeId=9f5313300e89e, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Tue May 01 05:05:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520477, encodeId=339a15204e7a5, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Tue May 01 05:05:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310548, encodeId=265931054832, content=粥状硬块如何处理?, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=41962298363, createdName=121ff658m46暂无昵称, createdTime=Mon Apr 30 03:52:54 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310454, encodeId=a9a5310454a7, content=对于初学者非常好.学习了.谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 29 19:41:05 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-07-04 hbwxf
  5. 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createdBy=41962298363, createdName=121ff658m46暂无昵称, createdTime=Mon Apr 30 03:52:54 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310454, encodeId=a9a5310454a7, content=对于初学者非常好.学习了.谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 29 19:41:05 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
  6. 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  7. 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  8. 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createdBy=41962298363, createdName=121ff658m46暂无昵称, createdTime=Mon Apr 30 03:52:54 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310454, encodeId=a9a5310454a7, content=对于初学者非常好.学习了.谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 29 19:41:05 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-05-01 jiyangfei
  9. 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createdBy=41962298363, createdName=121ff658m46暂无昵称, createdTime=Mon Apr 30 03:52:54 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310454, encodeId=a9a5310454a7, content=对于初学者非常好.学习了.谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 29 19:41:05 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-30 121ff658m46暂无昵称

    粥状硬块如何处理?

    0

  10. 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createdBy=41962298363, createdName=121ff658m46暂无昵称, createdTime=Mon Apr 30 03:52:54 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310454, encodeId=a9a5310454a7, content=对于初学者非常好.学习了.谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 29 19:41:05 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-29 虈亣靌

    对于初学者非常好.学习了.谢谢老师

    0

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Euro Prevent 2018:“将军肚”该减减啦!研究发现腹型肥胖与心血管风险增加有关

在近期召开的欧洲预防协会年会上,一项研究显示,即使在体重指数(BMI)正常的成人中,腹部脂肪也是一个心血管危险因素。

JACC:二尖瓣环钙化患者经导管二尖瓣置换术的预后研究

对于严重的二尖瓣环钙化(MAC)病人,外科的二尖瓣置换术的风险较高,目前在世界范围内,有数例MAC患者成功接受了经导管二尖瓣置换术(TMVR),并建立了MAC患者的TMVR注册中心。本研究的目的旨在评估该数据库中接受TMVR治疗的MAC患者的1年临床预后。本研究共纳入了106名接受有TMVR的MAC患者,患者的平均年龄为73 ± 12岁,女性占68%,平均的胸外科医师学会评分为15.3 ± 11.

JACC:个性化抗血小板治疗方案对冠心病患者疗效更佳

尽管抗血小板药物氯吡格雷在急性冠脉综合征(ACS)患者中仍在频繁使用,但由于基因的多态性,其在不同个体中的疗效差异较大。本研究的目的旨在评估与标准治疗相比,结合临床特征和患者遗传多态性的抗血小板药物(替卡格雷、氯吡格雷或普拉格雷)的选择是否更有疗效。本研究纳入了888例住院的ACS病人,并将其随机分入标准治疗组和药物基因组,在药物基因组中,对患者的ABCB1基因、CYP2C19*2基因和CYP2C

BMJ:芬兰人群房颤风险及因素研究

研究发现,对于55-75岁不同年龄段人群,致命性房颤的风险因素是相同的,存在一项风险因素则导致患者的致命性房颤风险增加15%

Sleep:交感神经调节障碍可能有助于解释慢性失眠症的心血管风险

一项最新的研究报告显示,慢性失眠与交感神经压力反射功能受损和神经对压力的反应增强有关,可增加心血管风险。该项研究结果发表于3月7日的《睡眠》杂志。

JACC:代谢健康的“胖子”近一半会发展为代谢综合征

目前,关于心血管代谢状态与代谢健康的肥胖(MHO)间的相关性仍未有定论。本研究提出假设,基线状态的MHO是短暂的,并且有可能转变为代谢综合征(MetS),而MetS就可以解释心血管疾病和全因死亡率所表现出的异质性了。本研究纳入了MESA临床研究中的6809名研究对象,经过平均12.2年时间的随访,分析结果发现,与代谢正常且体重正常的对象相比,基线水平的MHO个体与心血管疾病的发生无相关性,但其中有