JCEM:雌激素受体β基因变异与盐敏感性高血压相关

2017-09-29 MedSci MedSci原创

与年轻男性和老年妇女相比,年轻女性中高血压是不常见的。雌激素能保护大多数妇女抵抗高血压,因此,绝经后女性中的高血压发病率增加。由于存在一些绝经前妇女患高血压,因此,研究人员认为雌激素在这些妇女中可能起不同的作用。雌激素受体(ER)的遗传变异与心血管疾病有关。由ESR2编码的ER-β是二血管平滑肌中ER的主要表达。

背景:与年轻男性和老年妇女相比,年轻女性中高血压是不常见的。雌激素能保护大多数妇女抵抗高血压,因此,绝经后女性中的高血压发病率增加。由于存在一些绝经前妇女患高血压,因此,研究人员认为雌激素在这些妇女中可能起不同的作用。雌激素受体(ER)的遗传变异与心血管疾病有关。由ESR2编码的ER-β是二血管平滑肌中ER的主要表达。

目的:本研究旨在探讨ESR2的单核苷酸多态性(SNP)与血压的盐敏感性(SSBP)和女性的雌激素状态是否相关。

方法:研究人员在正常血压和高血压的妇女和男子的2个队列:国际高血压发病 (HyperPATH) (n=584)(发现)和墨西哥-美国高血压胰岛素抵抗研究 (HTN-IR) (n=662)(验证)中, 进行了ESR2和SSBP的候选基因关联研究。在ESR1(ERα)中的SNP被进行了分析。分析包括年轻女性(<51岁,绝经前,“充满雌激素”)和老年妇女(≥51年,绝经后,雌激素耗尽”)。男性分析根据匹配年龄来进行。

结果:对HyperPATH研究数据的多变量分析发现,ESR2变异与SSBP相关,如ESR2等位基因rs10144225小(风险)携带者与充满雌激素女性表现出SSBP之间有着一个显著的正相关(β= + 4.4mmHg/风险-等位基因,P = 0.004)。

该研究结果在HTN-IR绝经前妇女中得到了证实。HyperPATH队列分析显示与非携带者相比,风险等位基因携带者的醛固酮/肾素比值有所增加。没有检测到与ESR1相关联。

结论:在绝经前女性(充满雌激素)中,ESR2的等位基因rs10144225的变异与SSBP相关,而男性和绝经后妇女(雌激素耗尽)中则无相关性。自由盐饮食时不恰当的醛固酮水平可能介导了SSBP。

原始出处:

Manosroi W, Tan JW,et al.The Association of Estrogen Receptor-β Gene Variation with Salt Sensitive Blood Pressure.J Clin Endocrinol Metab. 2017 Sep 5. doi: 10.1210/jc.2017-00957. [Epub ahead of print]

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    2018-01-07 achengzhao
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    2018-05-04 smallant2015
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BPA,即双酚A,是由苯酚、丙酮在酸性介质中合成的,是环氧树脂、聚碳酸酯、聚砜、聚芳酯、酚醛树脂、不饱和聚酯树脂、阻燃剂等产品的重要原料。

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背景:尽管目前缺乏精确的分子机制,但雌激素能影响结直肠癌的发生和发展。目的:本研究旨在探讨雌激素代谢的前受体——人类CRC组织、TCGA Coad数据集、体内外的CRC模型研究中的类固醇硫酸酯酶(STS)和17β-羟类固醇脱氢酶的活性,及随后的非基因组雌激素信号,以及确定和哪种雌激素能改变CRC增殖和进展和其治疗的靶向通路。设计、设置、患者和干预:研究人员从绝经后妇女和根据年龄匹配的男性患者中,收