Arthritis Rheumatol:女性哮喘、慢阻肺与随后出现类风湿性关节炎的风险

2020-03-06 xiangting MedSci原创

哮喘和COPD均与偶发性RA的风险升高相关,而与吸烟状况/强度和其他潜在混杂因素无关。

由于RA相关性自身抗体的产生,推测气道炎症会引起类风湿性关节炎(RA)发病,并且吸烟是RA最强的环境危险因素。然而,慢性气道疾病在RA发展中的作用尚不清楚。这里调查了哮喘或COPD是否与RA相关。

对护士健康研究(NHS1988-2014)和NHSII1991-2015)中的205,153名女性进行了前瞻性队列研究。暴露是自我报告的医生诊断哮喘或COPD,并通过有效的补充问卷进行确认。结局是由2名风湿病医师通过病历审查确认的偶发性RA。通过两年一次的问卷调查对协变量(包括吸烟包-/状态)进行评估。使用Cox回归评估RA的多因素危险比(HRs)和95%置信区间(CIs)。

NHSNHSII4,384,471-年随访中,共确定了15,148例确诊为哮喘的女性,3,573例确诊为COPD的女性和1,060例偶发性RA。校正吸烟包-/状态等协变量后,与无哮喘/COPD相比,哮喘与RA的风险升高相关(HR 1.5395CI 1.24,1.88)。在从不吸烟者中,哮喘仍与RA风险升高相关(HR 1.5395CI 1.14,2.05)。COPD也与RA风险升高相关(HR 1.8995CI 1.31,2.75)。在55岁以上的曾经吸烟者亚组中,COPDRA的关联最明显(HR 2.2095CI 1.383.51)。

哮喘和COPD均与偶发性RA的风险升高相关,而与吸烟状况/强度和其他潜在混杂因素无关。这些结果为慢性气道炎症在RA发病机理中至关重要的假设提供了支持依据。

原始出处:

Julia A. Ford. Asthma, Chronic Obstructive Pulmonary Disease, and Subsequent Risk for Incident Rheumatoid Arthritis among Women: A Prospective Cohort Study. Arthritis Rheumatol. 04 March 2020.

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    2021-01-25 信念28

    0

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    2020-03-08 lmm397
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    2020-03-08 zhaojie88
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