Gastroenterology:急性胰腺炎导致胰腺癌长期风险增加

2018-02-12 zhangfan MedSci原创

研究证实急性胰腺炎与胰腺癌长期风险相关

急性胰腺炎是胰腺癌的风险因素之一,然而先前二者相关性研究结论互相矛盾。近日研究人员开展全国队列基础研究,对急性胰腺炎与胰腺癌之间的相关性进行考察。

研究人员考察了1980-2012年间丹麦全国急性胰腺炎住院患者资料,每个急性胰腺炎患者匹配5名年龄、性别相仿的非胰腺炎患者。采用Cox比例风险模型考察调整酒精、烟草以及Charlson并发症病指数后急性胰腺炎与胰腺癌之间的相关性。

41669名急性胰腺炎以及208340名对照志愿者参与研究。随访期间,急性胰腺炎患者胰腺癌风险显著提高,该风险随胰腺炎发病时间的推移曾降低的趋势,但发病5年后的胰腺癌风险仍较高(HR, 2.02;95% CI,1.57-2.61)。在急性胰腺炎患者中,发病2或5年后的胰腺癌绝对风险分别为0.68% (95% CI,0.61%-0.77%)和0.85% (95% CI,0.76%-0.94)。

研究证实急性胰腺炎与胰腺癌长期风险相关。

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    2018-05-27 许安
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