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CA Cancer J Clin：丙型肝炎病毒感染的肿瘤负担——临床角度

2017-09-12 MedSci MedSci原创

HCV癌症
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慢性丙型肝炎病毒（HCV）感染影响了全球数百万人，且与癌症的发生有关。直接作用的抗病毒药物（DaaS）已经改变了HCV的治疗模式，但是关于癌症患者丙型肝炎病毒感染的治疗却知之甚少。HCV感染的严重负担及关于癌症患者的HCV检测和管理的非决定性证据促使作者回顾文献并提出建议。推荐所有恶性血液病患者、造血细胞移植者和肝癌患者进行HCV筛查。对于其他类型癌症患者的HCV感染筛查缺乏基于共识的建议，但医生

慢性丙型肝炎病毒（HCV）感染影响了全球数百万人，且与癌症的发生有关。直接作用的抗病毒药物（DaaS）已经改变了HCV的治疗模式，但是关于癌症患者丙型肝炎病毒感染的治疗却知之甚少。HCV感染的严重负担及关于癌症患者的HCV检测和管理的非决定性证据促使作者回顾文献并提出建议。

推荐所有恶性血液病患者、造血细胞移植者和肝癌患者进行HCV筛查。对于其他类型癌症患者的HCV感染筛查缺乏基于共识的建议，但医生可以考虑至少筛选属于HCV感染高危人群患者，包括1945-1965年出生以及HCV感染的高危者。对HCV感染者应由专家评估，以评估HCV感染的严重程度、与HCV感染相关的合并症以及治疗机会。

DAA治疗基于患者的预后、癌症类型、癌症治疗计划，以及肝和病毒学参数。存在肝硬化史（甚至晚期纤维化）的丙型肝炎病毒感染的癌症患者以及那些处于肝脏疾病进展风险中的患者，尤其是存在HCV相关合并症的患者，应该持续跟进随访，而无论其是否有一个持续的病毒学应答，以确保及时发现和治疗肝细胞癌。HCV感染及其治疗不应看做是癌症治疗的禁忌症，也不应推迟癌症紧急治疗的起始时间。

原始出处：

Torres, H. A., Shigle, T. L., Hammoudi, N., Link, J. T., Samaniego, F., Kaseb, A. and Mallet, V., The oncologic burden of hepatitis C virus infection: A clinical perspective. CA: A Cancer Journal for Clinicians, 67: 411–431. doi:10.3322/caac.21403

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    2017-09-17 欣然梅斯

    学习了

    0

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    2017-09-16 欣然梅斯

    优质文章值得分享

    0

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    2017-09-14 zjubiostat

    #丙型肝炎#

    0

  4. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Tue Sep 12 21:38:15 CST 2017, time=2017-09-12, status=1, ipAttribution=)]
    2017-09-14 仁医06

    #丙型肝炎病毒#

    0

  5. 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    2017-09-13 欣然梅斯

    临床视角分析很到位.值得分享学习

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Tue Sep 12 21:38:15 CST 2017, time=2017-09-12, status=1, ipAttribution=)]
    2017-09-12 130****4638

    学习了谢谢分享

    0

  7. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/12/eadb34b6adc3de26b81abc8769bb43b0.jpg, createdBy=c3b52147621, createdName=可乐必妥, createdTime=Tue Sep 12 22:20:23 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243332, encodeId=6f8124333282, content=这篇文章让我又重新了解了这知识.针对病毒感染与肿瘤的相关性.对我们的临床研发又有了新的挑战和机遇, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJcE6dqqKFOJnI2tKRiamVbjq9qFtOPx4bUjMia1qlHia5sm0vCwsBpCGsFiajqg2BRLkhaNiaIEL8Mupg/0, createdBy=68fa2145692, createdName=欣然梅斯, createdTime=Tue Sep 12 21:41:47 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243327, encodeId=54ba24332e5f, content=学了.........., beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Tue Sep 12 21:38:15 CST 2017, time=2017-09-12, status=1, ipAttribution=)]
    2017-09-12 1ddf0692m34(暂无匿称)

    学习了.值得分享

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Tue Sep 12 21:38:15 CST 2017, time=2017-09-12, status=1, ipAttribution=)]
    2017-09-12 可乐必妥

    临床思维方式

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Tue Sep 12 21:38:15 CST 2017, time=2017-09-12, status=1, ipAttribution=)]
    2017-09-12 欣然梅斯

    这篇文章让我又重新了解了这知识.针对病毒感染与肿瘤的相关性.对我们的临床研发又有了新的挑战和机遇

    0

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    2017-09-12 135****7952平儿

    学了..........

    0

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