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Kidney Int：Intermedin上调a-klotho减轻慢性肾病大鼠血管钙化

2017-03-02 MedSci MedSci原创

Intermedin血管钙化慢性肾病
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a-klotho缺失参与血管钙化的发病过程。降钙素基因相关肽家族成员Intermedin（IMD）可抑制血管钙化。2016年发表在国际肾脏杂志的一篇研究，探讨心血管保护小肽IMD是否通过调节a-klotho表达从而抑制血管钙化。

a-klotho缺失参与血管钙化的发病过程。降钙素基因相关肽家族成员Intermedin（IMD）可抑制血管钙化。2016年发表在国际肾脏杂志的一篇研究，探讨心血管保护小肽IMD是否通过调节a-klotho表达从而抑制血管钙化。

5/6肾切除加维生素D3共同诱导慢性肾病大鼠血管钙化模型。在这一动物模型的钙化血管中， IMD表达水平降低，但其作用受体：降钙素受体样受体及受体活性修饰蛋白表达上调。在单纯慢性肾病大鼠血管钙化模型中a-klotho表达显著下调，而IMD处理可逆转这一变化，并抑制血管钙化。细胞实验中，IMD增加钙化血管平滑肌细胞中a-klotho蛋白表达。a-klotho敲低阻断了IMD对血管平滑肌细胞向成骨样细胞及钙化表型转化的抑制作用。IMD对a-klotho及细胞表型的调节被敲低受体及受体调节蛋白、PKA抑制剂H89所阻断。

总之，IMD通过受体及受体后PKA信号通路上调a-klotho，从而减轻血管钙化。

原始出处：Chang JR， Guo J， Wang Y，et al.Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho.Kidney Int. 2016 Mar；89(3)：586-600. doi： 10.1016/j.kint.2015.12.029. Epub 2016 Jan 28.

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    2017-11-17 apoenzyme

    #TERM#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1795643, encodeId=79bd1e95643d8, content=<a href='/topic/show?id=5fae1e281ac' target=_blank style='color:#2F92EE;'>#TERM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17281, encryptionId=5fae1e281ac, topicName=TERM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Fri Nov 17 05:45:00 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178641, encodeId=cbeb1e8641dc, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/30/dd6bade062cb598667f9f577194196c4.jpg, createdBy=422e1687020, createdName=Dr.jerry, createdTime=Mon Mar 06 00:10:45 CST 2017, time=2017-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407816, encodeId=f44b140e81649, content=<a href='/topic/show?id=ab471053548' target=_blank style='color:#2F92EE;'>#Klotho#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10535, encryptionId=ab471053548, topicName=Klotho)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Mar 03 19:45:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603005, encodeId=fdfd16030050b, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Fri Mar 03 19:45:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607275, encodeId=74c3160e2756a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Mar 03 19:45:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178481, encodeId=9b2d1e8481c1, content=刚看过这篇文章！, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Mar 02 13:08:11 CST 2017, time=2017-03-02, status=1, ipAttribution=)]
    2017-03-06 Dr.jerry

    谢谢分享

    0

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    2017-03-03 仁者大医

    #Klotho#

    0

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    2017-03-03 gwc389

    #kidney#

    0

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    2017-03-03 ms3994565386320060

    #Med#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1795643, encodeId=79bd1e95643d8, content=<a href='/topic/show?id=5fae1e281ac' target=_blank style='color:#2F92EE;'>#TERM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17281, encryptionId=5fae1e281ac, topicName=TERM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Fri Nov 17 05:45:00 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178641, encodeId=cbeb1e8641dc, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/30/dd6bade062cb598667f9f577194196c4.jpg, createdBy=422e1687020, createdName=Dr.jerry, createdTime=Mon Mar 06 00:10:45 CST 2017, time=2017-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407816, encodeId=f44b140e81649, content=<a href='/topic/show?id=ab471053548' target=_blank style='color:#2F92EE;'>#Klotho#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10535, encryptionId=ab471053548, topicName=Klotho)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Mar 03 19:45:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603005, encodeId=fdfd16030050b, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Fri Mar 03 19:45:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607275, encodeId=74c3160e2756a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Mar 03 19:45:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178481, encodeId=9b2d1e8481c1, content=刚看过这篇文章！, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Mar 02 13:08:11 CST 2017, time=2017-03-02, status=1, ipAttribution=)]
    2017-03-02 1ddf0692m34(暂无匿称)

    刚看过这篇文章！

    0